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• W1997466384 abstract "<b>Objective:</b> To investigate the expression of proangiogenic and antiangiogenic factors, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in retinal pigment epithelial (RPE) cells after photodynamic therapy (PDT), especially focusing on their change in the presence of triamcinolone acetonide. <b>Methods:</b> Firstly, the cellular uptake of verteporfin was quantified after confluent ARPE-19 (human retinal pigment epithelial) cells were exposed to 5 μg/ml verteporfin combined with or without 1 μg/ml triamcinolone acetonide for 1 h. Secondly, ARPE-19 cells exposed to various doses of verteporfin were irradiated with 120 mJ/cm² light. After incubation with or without 1 μg/ml triamcinolone acetonide for 2 days, cell viability and expressions of VEGF and PEDF were assessed. <b>Results:</b> Cellular uptake of verteporfin was not significantly changed by the presence of 1 μg/ml triamcinolone acetonide. In addition, 0.01–0.1 μg/ml of verteporfin showed a dose-dependent toxicity on the ARPE-19 cells 2 days after the light exposure. The presence of verteporfin at a concentration of 0.01 μg/ml did not affect the cell viability but significantly increased VEGF (p<0.001) and reduced PEDF (p = 0.03) expression. Administration of triamcinolone acetonide significantly suppressed both this increase in VEGF (p<0.001) and decrease in PEDF (p = 0.001). <b>Conclusions:</b> VEGF was increased and PEDF reduced in cultured RPE cells shortly after PDT even at a sublethal dose. Triamcinolone acetonide suppressed this proangiogenic response." @default.
• W1997466384 created "2016-06-24" @default.
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• W1997466384 date "2006-09-20" @default.
• W1997466384 modified "2023-10-18" @default.
• W1997466384 title "Triamcinolone acetonide suppresses early proangiogenic response in retinal pigment epithelial cells after photodynamic therapy in vitro" @default.
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• W1997466384 doi "https://doi.org/10.1136/bjo.2006.098004" @default.
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