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• W1997473653 abstract "Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindles in rats. The drug dose-dependently inhibited the phasic responses of alpha-rigidity in anemic decerebrate rats without showing marked inhibition of the tonic response. Tizanidine effectively depressed the crossed extensor reflex in chicks and depressed mono- and polysynaptic reflex potentials in rats; dorsal root reflex was increased transiently. Tizanidine had no effect on the neuromuscular junction in rats and [3H]diazepam binding in rat brain membrane. It is suggested that the depression by tizanidine of gamma-system and spinal reflexes contribute to muscle relaxation and anti-spastic effects and that mechanisms of action are different from those of other centrally acting muscle relaxants such as mephenesin and benzodiazepines." @default.
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• W1997473653 date "1986-01-01" @default.
• W1997473653 modified "2023-10-16" @default.
• W1997473653 title "Effects of tizanidine, a centrally acting muscle relaxant, on motor systems" @default.
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• W1997473653 doi "https://doi.org/10.1016/0306-3623(86)90130-8" @default.
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