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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997475045> ?p ?o ?g. }

• W1997475045 endingPage "67" @default.
• W1997475045 startingPage "57" @default.
• W1997475045 abstract "We have developed a novel polyethylenimine (PEI)-DNA vector formulation that is capable of efficient tumor-specific delivery after intravenous administration to nude mice. To further increase the specificity of delivery, we have attached the peptide CNGRC to the vector, which is specific for aminopeptidase N (CD13). The strategy for coupling this peptide to PEI was based on a novel method involving the strong affinity between phenyl(di)boronic acid (PDBA) and salicylhydroxamic acid (SHA) as well as a polyethylene glycol (PEG) linker to reduce steric hindrance between the vector and the peptide. In vitro assessment of targeting by the CNGRC/PEG/PEI/DNA vector carrying a beta-galactosidase (beta-Gal)-expressing plasmid showed as much as a 5-fold increase in transduction, relative to the untargeted PEG/PEI/DNA-betagal vector, of CD13-positive lung cancer, fibrosarcoma, bladder cancer, and human umbilical vein endothelial cells. Competition with free peptide resulted in up to a 90% reduction in delivery, indicating that gene delivery was specific for CD13-positive cells. Intravenous administration of the CNGRC/PEG/PEI/DNA-betagal vector to nude mice bearing subcutaneous tumors resulted in as much as a 12-fold increase in beta-Gal expression in tumors as compared with expression in either lungs or tumors from animals treated with the original PEI/DNA-betagal vector. In vivo transduction analysis using the CNGRC/PEG/PEI/DNA vector to target the intravenous delivery of a yellow fluorescence protein (YFP)-expressing plasmid to subcutaneous H1299 tumors confirmed delivery of YFP to both tumor cells and tumor endothelial cells. The use of this peptide to further increase tumor-specific delivery mediated by our novel PEI/DNA vector now provides a basis for developing tumor-targeted gene therapies for use in the clinical treatment of cancer." @default.
• W1997475045 created "2016-06-24" @default.
• W1997475045 creator A5009393730 @default.
• W1997475045 creator A5019179838 @default.
• W1997475045 creator A5075120165 @default.
• W1997475045 date "2005-01-01" @default.
• W1997475045 modified "2023-10-14" @default.
• W1997475045 title "Tumor-Specific Gene Delivery Mediated by a Novel Peptide–Polyethylenimine–DNA Polyplex Targeting Aminopeptidase N/CD13" @default.
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• W1997475045 doi "https://doi.org/10.1089/hum.2005.16.57" @default.
• W1997475045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15703489" @default.
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