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• W1997486236 abstract "In response to osmolarity, Salmonella enterica serotype Typhi (S. Typhi) regulates genes required for Vi capsular antigen expression oppositely to those required for motility and invasion. Previous studies suggest that osmoregulation of motility, invasion and capsule expression is mediated through the RcsC/RcsD/RcsB phosphorelay system. Here we performed gene expression profiling and functional studies to determine the role of TviA, an auxiliary protein of the RcsB response regulator, in controlling virulence gene expression in S. Typhi. TviA repressed expression of genes encoding flagella and the invasion-associated type III secretion system (T3SS-1) through repression of the flagellar regulators flhDC and fliZ, resulting in reduced invasion, reduced motility and reduced expression of FliC. Both RcsB and TviA repressed expression of flhDC, but only TviA altered flhDC expression in response to osmolarity. Introduction of tviA into S. enterica serotype Typhimurium rendered flhDC transcription sensitive to changes in osmolarity. These data suggest that the auxiliary TviA protein integrates a new regulatory input into the RcsB regulon of S. Typhi, thereby altering expression of genes encoding flagella, the Vi antigen and T3SS-1 in response to osmolarity." @default.
• W1997486236 created "2016-06-24" @default.
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• W1997486236 date "2009-10-01" @default.
• W1997486236 modified "2023-10-15" @default.
• W1997486236 title "The TviA auxiliary protein renders the<i>Salmonella enterica</i>serotype Typhi RcsB regulon responsive to changes in osmolarity" @default.
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• W1997486236 doi "https://doi.org/10.1111/j.1365-2958.2009.06859.x" @default.
• W1997486236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2763492" @default.
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