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• W1997486990 endingPage "213" @default.
• W1997486990 startingPage "41" @default.
• W1997486990 abstract "A number of therapeutic drugs with different structures and mechanisms of action have been reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes. The bioactivation gives rise to reactive metabolites/intermediates, which readily confer covalent binding to various target proteins by nucleophilic substitution and/or Schiff's base mechanism. These drugs include analgesics (e.g., acetaminophen), antibacterial agents (e.g., sulfonamides and macrolide antibiotics), anticancer drugs (e.g., irinotecan), antiepileptic drugs (e.g., carbamazepine), anti-HIV agents (e.g., ritonavir), antipsychotics (e.g., clozapine), cardiovascular drugs (e.g., procainamide and hydralazine), immunosupressants (e.g., cyclosporine A), inhalational anesthetics (e.g., halothane), nonsteroidal anti-inflammatory drugs (NSAIDSs) (e.g., diclofenac), and steroids and their receptor modulators (e.g., estrogens and tamoxifen). Some herbal and dietary constituents are also bioactivated to reactive metabolites capable of binding covalently and inactivating cytochrome P450s (CYPs). A number of important target proteins of drugs have been identified by mass spectrometric techniques and proteomic approaches. The covalent binding and formation of drug-protein adducts are generally considered to be related to drug toxicity, and selective protein covalent binding by drug metabolites may lead to selective organ toxicity. However, the mechanisms involved in the protein adduct-induced toxicity are largely undefined, although it has been suggested that drug-protein adducts may cause toxicity either through impairing physiological functions of the modified proteins or through immune-mediated mechanisms. In addition, mechanism-based inhibition of CYPs may result in toxic drug-drug interactions. The clinical consequences of drug bioactivation and covalent binding to proteins are unpredictable, depending on many factors that are associated with the administered drugs and patients. Further studies using proteomic and genomic approaches with high throughput capacity are needed to identify the protein targets of reactive drug metabolites, and to elucidate the structure-activity relationships of drug's covalent binding to proteins and their clinical outcomes." @default.
• W1997486990 created "2016-06-24" @default.
• W1997486990 creator A5027649946 @default.
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• W1997486990 creator A5087202351 @default.
• W1997486990 creator A5088285841 @default.
• W1997486990 date "2005-01-01" @default.
• W1997486990 modified "2023-10-17" @default.
• W1997486990 title "Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance" @default.
• W1997486990 cites W125678881 @default.
• W1997486990 cites W128703105 @default.
• W1997486990 cites W136647905 @default.
• W1997486990 cites W1479809193 @default.
• W1997486990 cites W1480633097 @default.
• W1997486990 cites W1482211895 @default.
• W1997486990 cites W1482600620 @default.
• W1997486990 cites W1485654772 @default.
• W1997486990 cites W1488147820 @default.
• W1997486990 cites W1489637669 @default.
• W1997486990 cites W1493745198 @default.
• W1997486990 cites W1496609148 @default.
• W1997486990 cites W1499393617 @default.
• W1997486990 cites W1505961841 @default.
• W1997486990 cites W1506618346 @default.
• W1997486990 cites W1510552728 @default.
• W1997486990 cites W1510812989 @default.
• W1997486990 cites W1511062685 @default.
• W1997486990 cites W1518280140 @default.
• W1997486990 cites W1520399629 @default.
• W1997486990 cites W1521492624 @default.
• W1997486990 cites W152488629 @default.
• W1997486990 cites W152662241 @default.
• W1997486990 cites W1534280303 @default.
• W1997486990 cites W1534585641 @default.
• W1997486990 cites W1539360768 @default.
• W1997486990 cites W1540019686 @default.
• W1997486990 cites W1541248284 @default.
• W1997486990 cites W1548033063 @default.
• W1997486990 cites W1548131797 @default.
• W1997486990 cites W1549717485 @default.
• W1997486990 cites W1550901848 @default.
• W1997486990 cites W1559172134 @default.
• W1997486990 cites W1567686906 @default.
• W1997486990 cites W1568733499 @default.
• W1997486990 cites W1573987088 @default.
• W1997486990 cites W1581280867 @default.
• W1997486990 cites W1583670148 @default.
• W1997486990 cites W1585209741 @default.
• W1997486990 cites W1586705032 @default.
• W1997486990 cites W1593202790 @default.
• W1997486990 cites W1596882142 @default.
• W1997486990 cites W1599264286 @default.
• W1997486990 cites W1599525955 @default.
• W1997486990 cites W1601460056 @default.
• W1997486990 cites W1602635797 @default.
• W1997486990 cites W1608691218 @default.
• W1997486990 cites W1639095272 @default.
• W1997486990 cites W164822238 @default.
• W1997486990 cites W166333908 @default.
• W1997486990 cites W1667958658 @default.
• W1997486990 cites W1670162774 @default.
• W1997486990 cites W1703321169 @default.
• W1997486990 cites W1708423019 @default.
• W1997486990 cites W1766115599 @default.
• W1997486990 cites W1774580137 @default.
• W1997486990 cites W1781217464 @default.
• W1997486990 cites W1797956629 @default.
• W1997486990 cites W1801981734 @default.
• W1997486990 cites W1809522263 @default.
• W1997486990 cites W1845962002 @default.
• W1997486990 cites W1851660174 @default.
• W1997486990 cites W1900675426 @default.
• W1997486990 cites W1912068049 @default.
• W1997486990 cites W1922623522 @default.
• W1997486990 cites W1952460809 @default.
• W1997486990 cites W1959962586 @default.
• W1997486990 cites W196233321 @default.
• W1997486990 cites W1964720812 @default.
• W1997486990 cites W1964932237 @default.
• W1997486990 cites W1965546941 @default.
• W1997486990 cites W1965912922 @default.
• W1997486990 cites W1966232756 @default.
• W1997486990 cites W1966250652 @default.
• W1997486990 cites W1966258408 @default.
• W1997486990 cites W1966288380 @default.
• W1997486990 cites W1966293314 @default.
• W1997486990 cites W1966350344 @default.
• W1997486990 cites W1966603503 @default.
• W1997486990 cites W1966612438 @default.
• W1997486990 cites W1966846971 @default.
• W1997486990 cites W1966943560 @default.
• W1997486990 cites W1966991584 @default.
• W1997486990 cites W1967058623 @default.
• W1997486990 cites W1967994046 @default.
• W1997486990 cites W1968251074 @default.
• W1997486990 cites W1968584338 @default.
• W1997486990 cites W1969138066 @default.

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