Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997494772> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1997494772 endingPage "363" @default.
- W1997494772 startingPage "357" @default.
- W1997494772 abstract "Two techniques were employed to define the site of diminished adenylate cyclase activity observed in age-rat myocardium. We previously reported no change in beta-adrenergic receptor number or affinity but decreased NaF- and 5'-guanylylimidodiphosphate (GppNHp)-stimulated adenylate cyclase activity with age in the rat myocardium. These data suggest a defect in either N-protein or the catalytic unit component of adenylate cyclase. N-protein activity was assessed by the ability of myocardial membrane extracts from 3-, 12, and 24-month-old Fischer 344 rats to complement the N-protein deficient cyc- S49 mouse lymphoma cell line. Catalytic unit activity was assessed by the ability of forskolin to stimulate adenylate cyclase in myocardial membranes from young and old rats. The results demonstrate that both N-protein activity and catalytic unit activity are diminished with age in the rat myocardium. However, since N-protein is present in excess relative to catalytic unit, the data are consistent with the hypothesis that the loss of catalytic unit activity accounts for the loss of overall enzyme activity. The effect is tissue-specific, since erythrocyte membranes do not show the same age-dependent loss of adenylate cyclase activity." @default.
- W1997494772 created "2016-06-24" @default.
- W1997494772 creator A5015589792 @default.
- W1997494772 creator A5074064171 @default.
- W1997494772 creator A5074595773 @default.
- W1997494772 date "1983-03-01" @default.
- W1997494772 modified "2023-10-15" @default.
- W1997494772 title "Age-associated decrease in the catalytic unit activitiy of rat myocardial adenylate cyclase" @default.
- W1997494772 cites W1576014737 @default.
- W1997494772 cites W1997342359 @default.
- W1997494772 cites W2012726555 @default.
- W1997494772 cites W2018097015 @default.
- W1997494772 cites W2019959771 @default.
- W1997494772 cites W2027496140 @default.
- W1997494772 cites W2072104521 @default.
- W1997494772 cites W2075676530 @default.
- W1997494772 cites W2091673685 @default.
- W1997494772 cites W2117253018 @default.
- W1997494772 cites W2321993038 @default.
- W1997494772 cites W2341814959 @default.
- W1997494772 cites W2414715525 @default.
- W1997494772 doi "https://doi.org/10.1016/0047-6374(83)90052-0" @default.
- W1997494772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6310279" @default.
- W1997494772 hasPublicationYear "1983" @default.
- W1997494772 type Work @default.
- W1997494772 sameAs 1997494772 @default.
- W1997494772 citedByCount "52" @default.
- W1997494772 countsByYear W19974947722013 @default.
- W1997494772 countsByYear W19974947722017 @default.
- W1997494772 crossrefType "journal-article" @default.
- W1997494772 hasAuthorship W1997494772A5015589792 @default.
- W1997494772 hasAuthorship W1997494772A5074064171 @default.
- W1997494772 hasAuthorship W1997494772A5074595773 @default.
- W1997494772 hasConcept C126322002 @default.
- W1997494772 hasConcept C134018914 @default.
- W1997494772 hasConcept C170493617 @default.
- W1997494772 hasConcept C180526460 @default.
- W1997494772 hasConcept C181199279 @default.
- W1997494772 hasConcept C185592680 @default.
- W1997494772 hasConcept C198684833 @default.
- W1997494772 hasConcept C2779276759 @default.
- W1997494772 hasConcept C2780069284 @default.
- W1997494772 hasConcept C55493867 @default.
- W1997494772 hasConcept C71924100 @default.
- W1997494772 hasConcept C86803240 @default.
- W1997494772 hasConceptScore W1997494772C126322002 @default.
- W1997494772 hasConceptScore W1997494772C134018914 @default.
- W1997494772 hasConceptScore W1997494772C170493617 @default.
- W1997494772 hasConceptScore W1997494772C180526460 @default.
- W1997494772 hasConceptScore W1997494772C181199279 @default.
- W1997494772 hasConceptScore W1997494772C185592680 @default.
- W1997494772 hasConceptScore W1997494772C198684833 @default.
- W1997494772 hasConceptScore W1997494772C2779276759 @default.
- W1997494772 hasConceptScore W1997494772C2780069284 @default.
- W1997494772 hasConceptScore W1997494772C55493867 @default.
- W1997494772 hasConceptScore W1997494772C71924100 @default.
- W1997494772 hasConceptScore W1997494772C86803240 @default.
- W1997494772 hasIssue "3-4" @default.
- W1997494772 hasLocation W19974947721 @default.
- W1997494772 hasLocation W19974947722 @default.
- W1997494772 hasOpenAccess W1997494772 @default.
- W1997494772 hasPrimaryLocation W19974947721 @default.
- W1997494772 hasRelatedWork W2009348767 @default.
- W1997494772 hasRelatedWork W2083829955 @default.
- W1997494772 hasRelatedWork W2084783976 @default.
- W1997494772 hasRelatedWork W2089788500 @default.
- W1997494772 hasRelatedWork W2402749343 @default.
- W1997494772 hasRelatedWork W2418757357 @default.
- W1997494772 hasRelatedWork W2418791397 @default.
- W1997494772 hasRelatedWork W2473208793 @default.
- W1997494772 hasRelatedWork W4290282087 @default.
- W1997494772 hasRelatedWork W45359555 @default.
- W1997494772 hasVolume "21" @default.
- W1997494772 isParatext "false" @default.
- W1997494772 isRetracted "false" @default.
- W1997494772 magId "1997494772" @default.
- W1997494772 workType "article" @default.