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- W1997495950 abstract "On the hypothesis that one carbon homologation of 4′‐selenonucleosides might relieve the steric repulsion between cellular kinases and bulky selenium, 5′‐homo‐4′‐Se‐d4Ns, 3 a–e, as anti‐HIV agents were designed and synthesized stereoselectively from d‐gulonic γ‐lactone, with the conversion of 2′,3′‐diol into the olefin as the key step. The anti‐HIV activity of all synthesized compounds, 5′‐homo‐4′‐Se‐d4Ns, was toxicity‐dependent, unlike normal 4′‐Se‐d4Ns, which were inactive against HIV‐1. This result indicates that 5′‐homo‐4′‐Se‐d4Ns might be phosphorylated by cellular kinases as per the hypothesis." @default.
- W1997495950 created "2016-06-24" @default.
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- W1997495950 date "1990-09-01" @default.
- W1997495950 modified "2023-09-26" @default.
- W1997495950 title "Computer-assisted structure-activity correlations of dideoxynucleoside analogs as potential anti-HIV drugs" @default.
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- W1997495950 doi "https://doi.org/10.1016/0166-3542(90)90030-b" @default.
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