FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997500258> ?p ?o ?g. }

• W1997500258 endingPage "1183" @default.
• W1997500258 startingPage "1177" @default.
• W1997500258 abstract "Objective: To study transmission dynamics during acute infection, during the aviremic phase over the period of early antiretroviral therapy (ART) and during the phase of viral rebound after early treatment was stopped. Methods: Transmission dynamics was assessed within 111 patients, enrolled in the Zurich primary HIV infection study, by molecular epidemiological methods using pol sequences from genotypic resistance tests and clonal env C2–V3–C3 sequences. Coclustering of Zurich primary HIV infection sequences with 12 303 sequences from 8837 HIV-positive patients enrolled in the multisite Swiss HIV Cohort Study was identified. Furthermore, we investigated transmission patterns within phylogenetic clusters by using longitudinal clinical data and analyzed HIV transmission by stage of infection and attempted to localize transmission events to periods before or after early ART. Results: Six transmission clusters comprising 20 men having sex with men were identified. Furthermore, linkage to eight men having sex with men from the Swiss HIV Cohort Study could be established. Strikingly, we detected at least five new primary infection events originating from Zurich primary HIV infection patients within 16–61 weeks after stopping early ART. Viral loads of likely index patients varied from 314 up to 1 690 000 HIV-1 RNA copies/ml of plasma at the estimated time of infection. Conclusion: The large number of new infections originating from men having sex with men who stopped early ART indicates that current preventive efforts are insufficient. In contrast, these patients showed no adherence problems. These findings argue for early, continuous ART in sexually active HIV-1-infected persons not only for individual patient benefits but also specifically to reduce the spread of HIV-1." @default.
• W1997500258 created "2016-06-24" @default.
• W1997500258 creator A5001523145 @default.
• W1997500258 creator A5001947909 @default.
• W1997500258 creator A5020901993 @default.
• W1997500258 creator A5033010131 @default.
• W1997500258 creator A5040255480 @default.
• W1997500258 creator A5052132429 @default.
• W1997500258 creator A5052780767 @default.
• W1997500258 creator A5060217492 @default.
• W1997500258 creator A5061028016 @default.
• W1997500258 creator A5066667348 @default.
• W1997500258 creator A5078674653 @default.
• W1997500258 creator A5086552318 @default.
• W1997500258 creator A5088187599 @default.
• W1997500258 date "2010-05-15" @default.
• W1997500258 modified "2023-09-23" @default.
• W1997500258 title "HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men" @default.
• W1997500258 cites W101663930 @default.
• W1997500258 cites W1735143085 @default.
• W1997500258 cites W1907128970 @default.
• W1997500258 cites W1984470007 @default.
• W1997500258 cites W1992891916 @default.
• W1997500258 cites W2005319454 @default.
• W1997500258 cites W2014611423 @default.
• W1997500258 cites W2015424427 @default.
• W1997500258 cites W2026315728 @default.
• W1997500258 cites W2040177363 @default.
• W1997500258 cites W2041424522 @default.
• W1997500258 cites W2052857100 @default.
• W1997500258 cites W2067464226 @default.
• W1997500258 cites W2083690910 @default.
• W1997500258 cites W2105009359 @default.
• W1997500258 cites W2109046728 @default.
• W1997500258 cites W2114202466 @default.
• W1997500258 cites W2125121305 @default.
• W1997500258 cites W2127774996 @default.
• W1997500258 cites W2136901708 @default.
• W1997500258 cites W2141054917 @default.
• W1997500258 cites W2147547300 @default.
• W1997500258 cites W2155449170 @default.
• W1997500258 cites W2162990662 @default.
• W1997500258 cites W2163036286 @default.
• W1997500258 cites W2167474405 @default.
• W1997500258 cites W2170578204 @default.
• W1997500258 cites W2171486852 @default.
• W1997500258 cites W2171689424 @default.
• W1997500258 cites W2314461521 @default.
• W1997500258 doi "https://doi.org/10.1097/qad.0b013e328338e4de" @default.
• W1997500258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20386427" @default.
• W1997500258 hasPublicationYear "2010" @default.
• W1997500258 type Work @default.
• W1997500258 sameAs 1997500258 @default.
• W1997500258 citedByCount "62" @default.
• W1997500258 countsByYear W19975002582012 @default.
• W1997500258 countsByYear W19975002582013 @default.
• W1997500258 countsByYear W19975002582014 @default.
• W1997500258 countsByYear W19975002582015 @default.
• W1997500258 countsByYear W19975002582016 @default.
• W1997500258 countsByYear W19975002582017 @default.
• W1997500258 countsByYear W19975002582019 @default.
• W1997500258 countsByYear W19975002582020 @default.
• W1997500258 countsByYear W19975002582021 @default.
• W1997500258 countsByYear W19975002582022 @default.
• W1997500258 crossrefType "journal-article" @default.
• W1997500258 hasAuthorship W1997500258A5001523145 @default.
• W1997500258 hasAuthorship W1997500258A5001947909 @default.
• W1997500258 hasAuthorship W1997500258A5020901993 @default.
• W1997500258 hasAuthorship W1997500258A5033010131 @default.
• W1997500258 hasAuthorship W1997500258A5040255480 @default.
• W1997500258 hasAuthorship W1997500258A5052132429 @default.
• W1997500258 hasAuthorship W1997500258A5052780767 @default.
• W1997500258 hasAuthorship W1997500258A5060217492 @default.
• W1997500258 hasAuthorship W1997500258A5061028016 @default.
• W1997500258 hasAuthorship W1997500258A5066667348 @default.
• W1997500258 hasAuthorship W1997500258A5078674653 @default.
• W1997500258 hasAuthorship W1997500258A5086552318 @default.
• W1997500258 hasAuthorship W1997500258A5088187599 @default.
• W1997500258 hasConcept C107130276 @default.
• W1997500258 hasConcept C119599485 @default.
• W1997500258 hasConcept C126322002 @default.
• W1997500258 hasConcept C127413603 @default.
• W1997500258 hasConcept C142462285 @default.
• W1997500258 hasConcept C144024400 @default.
• W1997500258 hasConcept C149923435 @default.
• W1997500258 hasConcept C159047783 @default.
• W1997500258 hasConcept C197746943 @default.
• W1997500258 hasConcept C201903717 @default.
• W1997500258 hasConcept C203014093 @default.
• W1997500258 hasConcept C2776939746 @default.
• W1997500258 hasConcept C2776983459 @default.
• W1997500258 hasConcept C2993143319 @default.
• W1997500258 hasConcept C3013748606 @default.
• W1997500258 hasConcept C3019340110 @default.
• W1997500258 hasConcept C71924100 @default.
• W1997500258 hasConcept C72563966 @default.
• W1997500258 hasConcept C761482 @default.
• W1997500258 hasConceptScore W1997500258C107130276 @default.

• next