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- W1997518684 abstract "BF-2 cells, an established cell line derived from bluegill sunfish, (Lepomis macrochirus), were exposed to 18 organic toxicants, with cytotoxicity being assayed by the neutral red (NR) technique. Based on the concentration of toxicant that reduced lysosomal uptake of neutral red by 50% (NR50), the rank order of cytotoxicity was methyl mercury > pentachlorophenol > 2,3,5,6-tetrachlorophenol > 2,3,5-trichlorophenol > 2,3-dinitrotoluene > 2,4,6-trichlorophenol > 2,4-dichlorophenol > 2,4-dichlorotoluene > 6-chloro-3-hydroxytoluene > o-chlorotoluene > 4-chlorophenol > 2-chlorophenol, 2,4-dimethylphenol > 2,4-dinitrophenol > 4-nitrophenol > 3-methylphenol > phenol > toluene. Published in vivo LC50 values were identified for 11 of the 18 test agents and, with the exception of 2,4-dinitrophenol, there was a good correlation between the in vitro cytotoxicity of the test agents and their in vivo waterborne acute toxocity. The potencies of the substituted phenolics and chlorinated toluenes as determined by the in vitro cytotoxocity assay correlated strongly with their log octanol/water partition coefficients (log P). However, the toxicity of 2,3-dinitrotoluene in vitro, and apparently also in vivo, was not a function of its log P value." @default.
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- W1997518684 date "1987-02-01" @default.
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- W1997518684 title "In Vitro cytotoxicity of organic pollutants to bluegil sunfish (BF-2) cells" @default.
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- W1997518684 doi "https://doi.org/10.1016/s0013-9351(87)80024-5" @default.
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