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- W1997521244 abstract "The potential of organic–inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells." @default.
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- W1997521244 date "2012-01-01" @default.
- W1997521244 modified "2023-10-10" @default.
- W1997521244 title "Organic–inorganic nanovesicles for doxorubicin storage and release" @default.
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- W1997521244 doi "https://doi.org/10.1039/c2sm07452d" @default.
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