FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997534905> ?p ?o ?g. }

• W1997534905 endingPage "72" @default.
• W1997534905 startingPage "61" @default.
• W1997534905 abstract "A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its clustered character that leads to the formation of complex lesions challenging the cellular repair mechanisms. The most widely investigated such complex lesion is the DNA double strand break (DSB). DSBs undermine chromatin stability and challenge the repair machinery because an intact template strand is lacking to assist restoration of integrity and sequence in the DNA molecule. Therefore, cells have evolved a sophisticated machinery to detect DSBs and coordinate a response on the basis of inputs from various sources. A central function of cellular responses to DSBs is the coordination of DSB repair. Two conceptually different mechanisms can in principle remove DSBs from the genome of cells of higher eukaryotes. Homologous recombination repair (HRR) uses as template a homologous DNA molecule and is therefore error-free; it functions preferentially in the S and G2 phases. Non-homologous end joining (NHEJ), on the other hand, simply restores DNA integrity by joining the two ends, is error prone as sequence is only fortuitously preserved and active throughout the cell cycle. The basis of DSB repair pathway choice remains unknown, but cells of higher eukaryotes appear programmed to utilize preferentially NHEJ. Recent work suggests that when the canonical DNA-PK dependent pathway of NHEJ (D-NHEJ), becomes compromised an alternative NHEJ pathway and not HRR substitutes in a quasi-backup function (B-NHEJ). Here, we outline aspects of DSB induction by IR and review the mechanisms of their processing in cells of higher eukaryotes. We place particular emphasis on backup pathways of NHEJ and summarize their increasing significance in various cellular processes, as well as their potential contribution to carcinogenesis." @default.
• W1997534905 created "2016-06-24" @default.
• W1997534905 creator A5056388836 @default.
• W1997534905 creator A5076541190 @default.
• W1997534905 date "2011-06-01" @default.
• W1997534905 modified "2023-10-18" @default.
• W1997534905 title "Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways" @default.
• W1997534905 cites W1550068234 @default.
• W1997534905 cites W1964370576 @default.
• W1997534905 cites W1967892265 @default.
• W1997534905 cites W1968813490 @default.
• W1997534905 cites W1969173539 @default.
• W1997534905 cites W1970891016 @default.
• W1997534905 cites W1972222169 @default.
• W1997534905 cites W1974327959 @default.
• W1997534905 cites W1977106716 @default.
• W1997534905 cites W1978054036 @default.
• W1997534905 cites W1978671317 @default.
• W1997534905 cites W1979657436 @default.
• W1997534905 cites W1980034972 @default.
• W1997534905 cites W1980636468 @default.
• W1997534905 cites W1981255217 @default.
• W1997534905 cites W1986262530 @default.
• W1997534905 cites W1987345634 @default.
• W1997534905 cites W1989136612 @default.
• W1997534905 cites W1989859525 @default.
• W1997534905 cites W1990909659 @default.
• W1997534905 cites W1994035481 @default.
• W1997534905 cites W1995920076 @default.
• W1997534905 cites W1998723823 @default.
• W1997534905 cites W1999035626 @default.
• W1997534905 cites W1999515288 @default.
• W1997534905 cites W2001330742 @default.
• W1997534905 cites W2001748204 @default.
• W1997534905 cites W2001784394 @default.
• W1997534905 cites W2002231685 @default.
• W1997534905 cites W2003561588 @default.
• W1997534905 cites W2003673006 @default.
• W1997534905 cites W2004038052 @default.
• W1997534905 cites W2005088616 @default.
• W1997534905 cites W2006268714 @default.
• W1997534905 cites W2007377687 @default.
• W1997534905 cites W2009150623 @default.
• W1997534905 cites W2010711320 @default.
• W1997534905 cites W2011522975 @default.
• W1997534905 cites W2011984142 @default.
• W1997534905 cites W2012063681 @default.
• W1997534905 cites W2013823880 @default.
• W1997534905 cites W2014199526 @default.
• W1997534905 cites W2014238550 @default.
• W1997534905 cites W2015090136 @default.
• W1997534905 cites W2015414930 @default.
• W1997534905 cites W2016949180 @default.
• W1997534905 cites W2016949934 @default.
• W1997534905 cites W2022163673 @default.
• W1997534905 cites W2022873453 @default.
• W1997534905 cites W2025726479 @default.
• W1997534905 cites W2026959390 @default.
• W1997534905 cites W2028408120 @default.
• W1997534905 cites W2029065442 @default.
• W1997534905 cites W2032117887 @default.
• W1997534905 cites W2033450927 @default.
• W1997534905 cites W2035389897 @default.
• W1997534905 cites W2038573275 @default.
• W1997534905 cites W2038860354 @default.
• W1997534905 cites W2039471307 @default.
• W1997534905 cites W2044963929 @default.
• W1997534905 cites W2046916766 @default.
• W1997534905 cites W2047672338 @default.
• W1997534905 cites W2050164541 @default.
• W1997534905 cites W2051193631 @default.
• W1997534905 cites W2051211176 @default.
• W1997534905 cites W2051426742 @default.
• W1997534905 cites W2052239835 @default.
• W1997534905 cites W2052289985 @default.
• W1997534905 cites W2052714004 @default.
• W1997534905 cites W2053311488 @default.
• W1997534905 cites W2053405779 @default.
• W1997534905 cites W2055233276 @default.
• W1997534905 cites W2055367037 @default.
• W1997534905 cites W2056527762 @default.
• W1997534905 cites W2058332866 @default.
• W1997534905 cites W2058375396 @default.
• W1997534905 cites W2059239585 @default.
• W1997534905 cites W2059707331 @default.
• W1997534905 cites W2064771448 @default.
• W1997534905 cites W2065849886 @default.
• W1997534905 cites W2066867862 @default.
• W1997534905 cites W2068449224 @default.
• W1997534905 cites W2068668324 @default.
• W1997534905 cites W2069964111 @default.
• W1997534905 cites W2071188390 @default.
• W1997534905 cites W2072325705 @default.
• W1997534905 cites W2072854810 @default.
• W1997534905 cites W2074024522 @default.
• W1997534905 cites W2076768032 @default.
• W1997534905 cites W2077892030 @default.
• W1997534905 cites W2079013544 @default.

• next