FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997538950> ?p ?o ?g. }

• W1997538950 endingPage "258" @default.
• W1997538950 startingPage "258" @default.
• W1997538950 abstract "720 We have previously shown that CTLA4Ig prevents the development of chronic allograft rejection in the Lew to F344 rat heterotopic cardiac transplant model (JCI, 1996; 97: 833). CTLA4Ig blocks both B7-1 and B7-2: two costimulatory molecules which are known to exhibit differing temporal expression and functional characteristics in vitro and in vivo. To dissect the individual role of B7-1 in the pathogenesis of chronic allograft rejection we used a mutant form of CTLA4Ig, Y100F, which blocks B7-1 but not B7-2. Early administration of Y100F, either as a single dose (0.5mg i.p.) (group A, n=5) or multiple doses (0.5mg i.p. 2x/wk) (group B, n=4) starting day 2 post transplantation failed to prolong graft survival as compared to untreated control (Group C, n=6; all animals rejected their grafts within 3 weeks). This is in sharp contrast to the effects of CTLA4Ig given at this time point which results in prolonged graft survival (> 100 days) in more than 60% of animals. We then studied the effects of late blockade of B7-1. Animals received 30 days of low dose CsA (1 mg1day s.c.) to prevent acute rejection followed by either Y100F (group D; n=8), or control fusion protein (group E, n=19) at 0.5mg 2x/wk for 4 wks starting 1 month post transplantation, or continuous CsA (1 mg1day s.c.) (group F, n=5). Both selective late blockade of B7-1 by Y100F (D) and continuous CsA treatment (F) significantly prolonged allograft survival but only Y100F treatment interupted development of graft arteriosclerosis, the sine qua non of chronic allograft rejection. Mean arteriosclerotic score in grafts surviving >100days was 0.91±0.5* in the Y100F group (D), compared to 1.76±1.53 in the continuous CsA treated group (F) and 1.72±0.53 in the control fusion protein group (E). Furthermore, histological analysis of graft specimens revealed significantly less graft fibrosis in the Y100F treated groups (D) compared to control (E) and continuous CsA (F) groups. Consistent with these findings, semi-quantitative PCR revealed significantly reduced tissue expression of TGF-β mRNA in grafts from the Y100F treated group. These data show that blocking B7-1 late but not early posttransplantation is effective at interrupting progression of chronic rejection. These findings are consistent with the later temporal expression of B7-1 during the alloimmune response. *p<0.05 compared to control group (D).Figure" @default.
• W1997538950 created "2016-06-24" @default.
• W1997538950 creator A5028211848 @default.
• W1997538950 creator A5036437333 @default.
• W1997538950 creator A5046964205 @default.
• W1997538950 creator A5054858357 @default.
• W1997538950 creator A5058866981 @default.
• W1997538950 creator A5067871845 @default.
• W1997538950 date "1998-05-01" @default.
• W1997538950 modified "2023-09-26" @default.
• W1997538950 title "LATE BLOCKADE OF B7-1 COSTIMULATION INTERRUPTS THE DEVELOPMENT OF CHRONIC REJECTION IN A RAT MODEL OF CARDIAC TRANSPLANTATION." @default.
• W1997538950 doi "https://doi.org/10.1097/00007890-199805131-00716" @default.
• W1997538950 hasPublicationYear "1998" @default.
• W1997538950 type Work @default.
• W1997538950 sameAs 1997538950 @default.
• W1997538950 citedByCount "0" @default.
• W1997538950 crossrefType "journal-article" @default.
• W1997538950 hasAuthorship W1997538950A5028211848 @default.
• W1997538950 hasAuthorship W1997538950A5036437333 @default.
• W1997538950 hasAuthorship W1997538950A5046964205 @default.
• W1997538950 hasAuthorship W1997538950A5054858357 @default.
• W1997538950 hasAuthorship W1997538950A5058866981 @default.
• W1997538950 hasAuthorship W1997538950A5067871845 @default.
• W1997538950 hasConcept C126322002 @default.
• W1997538950 hasConcept C150903083 @default.
• W1997538950 hasConcept C170493617 @default.
• W1997538950 hasConcept C203014093 @default.
• W1997538950 hasConcept C207001950 @default.
• W1997538950 hasConcept C2778468042 @default.
• W1997538950 hasConcept C2778849806 @default.
• W1997538950 hasConcept C2780942790 @default.
• W1997538950 hasConcept C2911091166 @default.
• W1997538950 hasConcept C71924100 @default.
• W1997538950 hasConcept C86803240 @default.
• W1997538950 hasConcept C90924648 @default.
• W1997538950 hasConcept C98274493 @default.
• W1997538950 hasConceptScore W1997538950C126322002 @default.
• W1997538950 hasConceptScore W1997538950C150903083 @default.
• W1997538950 hasConceptScore W1997538950C170493617 @default.
• W1997538950 hasConceptScore W1997538950C203014093 @default.
• W1997538950 hasConceptScore W1997538950C207001950 @default.
• W1997538950 hasConceptScore W1997538950C2778468042 @default.
• W1997538950 hasConceptScore W1997538950C2778849806 @default.
• W1997538950 hasConceptScore W1997538950C2780942790 @default.
• W1997538950 hasConceptScore W1997538950C2911091166 @default.
• W1997538950 hasConceptScore W1997538950C71924100 @default.
• W1997538950 hasConceptScore W1997538950C86803240 @default.
• W1997538950 hasConceptScore W1997538950C90924648 @default.
• W1997538950 hasConceptScore W1997538950C98274493 @default.
• W1997538950 hasIssue "Supplement" @default.
• W1997538950 hasLocation W19975389501 @default.
• W1997538950 hasOpenAccess W1997538950 @default.
• W1997538950 hasPrimaryLocation W19975389501 @default.
• W1997538950 hasRelatedWork W2051519978 @default.
• W1997538950 hasRelatedWork W2092637011 @default.
• W1997538950 hasRelatedWork W2108183932 @default.
• W1997538950 hasRelatedWork W2317262530 @default.
• W1997538950 hasRelatedWork W2322088208 @default.
• W1997538950 hasRelatedWork W2327963981 @default.
• W1997538950 hasRelatedWork W2414276012 @default.
• W1997538950 hasRelatedWork W2999185506 @default.
• W1997538950 hasRelatedWork W3032540778 @default.
• W1997538950 hasRelatedWork W4245785827 @default.
• W1997538950 hasVolume "65" @default.
• W1997538950 isParatext "false" @default.
• W1997538950 isRetracted "false" @default.
• W1997538950 magId "1997538950" @default.
• W1997538950 workType "article" @default.