FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997541516> ?p ?o ?g. }

• W1997541516 endingPage "504" @default.
• W1997541516 startingPage "495" @default.
• W1997541516 abstract "Male reproductive health is compromised with increased paternal age, due at least in part, to an increased frequency of de novo germline mutations. Because of technical and sample limitations, there is a dearth of empirical information on the mechanism(s) that mediate this age-related increase in mutant frequency. To study this phenomenon, investigators have used as a model system a transgenic mouse strain that carries a lacI mutagenesis reporter transgene. This transgene displays a paternal age effect and overcomes many of the technical difficulties that have inhibited experimental analyses of age-related changes in the male germline. In this study, approximately 300 mutant lacI transgenes were recovered from defined spermatogenic cell types obtained from various aged lacI transgenic mice and sequenced. The spectrum representing mutations from spermatogenic cells of old mice revealed an increased prevalence of transversions compared to spectra for young and middle-aged mice. Five mutation hotspots were identified in spectra for spermatogenic cells from young and middle-aged mice, but no hotspots were identified in the spectrum for spermatogenic cells from old mice. These results suggest that the challenges to germline DNA change as the animal ages and that the increased mutant frequency observed with increased paternal age is not simply a greater accumulation of mutagenic events characteristic of spermatogenic cells from the young animal." @default.
• W1997541516 created "2016-06-24" @default.
• W1997541516 creator A5029691634 @default.
• W1997541516 creator A5039244523 @default.
• W1997541516 creator A5051119702 @default.
• W1997541516 creator A5051661000 @default.
• W1997541516 creator A5060351749 @default.
• W1997541516 creator A5062264266 @default.
• W1997541516 date "2004-05-04" @default.
• W1997541516 modified "2023-10-18" @default.
• W1997541516 title "Mutation spectral changes in spermatogenic cells obtained from old mice" @default.
• W1997541516 cites W103650626 @default.
• W1997541516 cites W142190260 @default.
• W1997541516 cites W1521702495 @default.
• W1997541516 cites W1540318286 @default.
• W1997541516 cites W1557675999 @default.
• W1997541516 cites W1651084032 @default.
• W1997541516 cites W1924766827 @default.
• W1997541516 cites W1944848399 @default.
• W1997541516 cites W1970600993 @default.
• W1997541516 cites W1974058163 @default.
• W1997541516 cites W1974590824 @default.
• W1997541516 cites W1979413007 @default.
• W1997541516 cites W1979562269 @default.
• W1997541516 cites W1984213429 @default.
• W1997541516 cites W1984573136 @default.
• W1997541516 cites W1985579253 @default.
• W1997541516 cites W1985630852 @default.
• W1997541516 cites W1986773920 @default.
• W1997541516 cites W1989007469 @default.
• W1997541516 cites W1994851065 @default.
• W1997541516 cites W2000026908 @default.
• W1997541516 cites W2007998684 @default.
• W1997541516 cites W2010797796 @default.
• W1997541516 cites W2016175366 @default.
• W1997541516 cites W2021894489 @default.
• W1997541516 cites W2022615484 @default.
• W1997541516 cites W2026711486 @default.
• W1997541516 cites W2032941539 @default.
• W1997541516 cites W2033187951 @default.
• W1997541516 cites W2038212913 @default.
• W1997541516 cites W2043748488 @default.
• W1997541516 cites W2044681022 @default.
• W1997541516 cites W2067028787 @default.
• W1997541516 cites W2067506064 @default.
• W1997541516 cites W2067951632 @default.
• W1997541516 cites W2070253074 @default.
• W1997541516 cites W2070411999 @default.
• W1997541516 cites W2071709406 @default.
• W1997541516 cites W2076547880 @default.
• W1997541516 cites W2077751281 @default.
• W1997541516 cites W2079464968 @default.
• W1997541516 cites W2081617336 @default.
• W1997541516 cites W2085131602 @default.
• W1997541516 cites W2086167074 @default.
• W1997541516 cites W2089411437 @default.
• W1997541516 cites W2090285110 @default.
• W1997541516 cites W2092780887 @default.
• W1997541516 cites W2093170540 @default.
• W1997541516 cites W2130627567 @default.
• W1997541516 cites W2133412417 @default.
• W1997541516 cites W2139688550 @default.
• W1997541516 cites W2158811885 @default.
• W1997541516 cites W2164542791 @default.
• W1997541516 cites W2168035946 @default.
• W1997541516 cites W2278343092 @default.
• W1997541516 cites W2315512556 @default.
• W1997541516 cites W2325266334 @default.
• W1997541516 cites W2414005403 @default.
• W1997541516 doi "https://doi.org/10.1016/j.dnarep.2004.01.005" @default.
• W1997541516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15084311" @default.
• W1997541516 hasPublicationYear "2004" @default.
• W1997541516 type Work @default.
• W1997541516 sameAs 1997541516 @default.
• W1997541516 citedByCount "22" @default.
• W1997541516 countsByYear W19975415162012 @default.
• W1997541516 countsByYear W19975415162013 @default.
• W1997541516 countsByYear W19975415162014 @default.
• W1997541516 countsByYear W19975415162015 @default.
• W1997541516 countsByYear W19975415162016 @default.
• W1997541516 countsByYear W19975415162017 @default.
• W1997541516 countsByYear W19975415162018 @default.
• W1997541516 countsByYear W19975415162019 @default.
• W1997541516 countsByYear W19975415162020 @default.
• W1997541516 crossrefType "journal-article" @default.
• W1997541516 hasAuthorship W1997541516A5029691634 @default.
• W1997541516 hasAuthorship W1997541516A5039244523 @default.
• W1997541516 hasAuthorship W1997541516A5051119702 @default.
• W1997541516 hasAuthorship W1997541516A5051661000 @default.
• W1997541516 hasAuthorship W1997541516A5060351749 @default.
• W1997541516 hasAuthorship W1997541516A5062264266 @default.
• W1997541516 hasConcept C102230213 @default.
• W1997541516 hasConcept C102306862 @default.
• W1997541516 hasConcept C104317684 @default.
• W1997541516 hasConcept C109825262 @default.
• W1997541516 hasConcept C113629113 @default.
• W1997541516 hasConcept C134305767 @default.
• W1997541516 hasConcept C13514818 @default.

• next