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- W1997542405 abstract "Zolpidem is a widely used hypnotic that binds preferentially to α1GABAA receptors. We determined the role of these receptors in the effects of zolpidem on sleep in mutant mice carrying zolpidem-insensitive α1GABAA receptors and wild-type controls. Sleep was promoted by zolpidem in both genotypes. In wild-type mice non-REM sleep EEG power was markedly reduced in a broad frequency band >5 or 9 Hz after 5 and 10 mg/kg zolpidem, respectively. In mutants a power reduction appeared at the highest dose only, and was restricted to some low frequencies and the 9–10 Hz bin. We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by α1GABAA receptors." @default.
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- W1997542405 date "2004-10-01" @default.
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- W1997542405 title "Sleep EEG changes after zolpidem in mice" @default.
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- W1997542405 doi "https://doi.org/10.1097/00001756-200410050-00031" @default.
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