Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997552453> ?p ?o ?g. }
- W1997552453 endingPage "1675" @default.
- W1997552453 startingPage "1665" @default.
- W1997552453 abstract "Abstract Alpha macroglobulins are large glycoproteins which are present in the body fluids of both invertebrates and vertebrates. Alpha‐2‐macroglobulin (α 2 M), a key member of alpha macroglobulin superfamily, is a high‐molecular weight homotetrameric glycoprotein. α 2 M has many diversified and complex functions, but it is primarily known by its ability to inhibit a broad spectrum of proteases without the direct blockage of the protease active site. α 2 M is also known to be involved in the regulation, transport, and a host of other functions. For example, apart from inhibiting proteinases, it regulates binding of transferrin to its surface receptor, binds defensin and myelin basic protein, etc., binds several important cytokines, including basic fibroblast growth factor (bFGF), platelet‐derived growth factor (PDGF), nerve growth factor (NGF), interleukin‐1β (IL‐1β), and interleukin‐6 (IL‐6), and modify their biological activity. α 2 M also binds a number of hormones and regulates their activity. α 2 M is said to protect the body against various infections, and hence, can be used as a biomarker for the diagnosis and prognosis of a number of diseases. However, this multipurpose antiproteinse is not “fail safe” and could be damaged by reactive species generated endogenously or exogenously, leading to various pathophysiological conditions. J. Cell. Physiol. 228: 1665–1675, 2013. © 2012 Wiley Periodicals, Inc." @default.
- W1997552453 created "2016-06-24" @default.
- W1997552453 creator A5014931462 @default.
- W1997552453 creator A5026066843 @default.
- W1997552453 creator A5042446340 @default.
- W1997552453 date "2013-04-18" @default.
- W1997552453 modified "2023-10-11" @default.
- W1997552453 title "Alpha‐2‐macroglobulin: A physiological guardian" @default.
- W1997552453 cites W1494388590 @default.
- W1997552453 cites W1510722505 @default.
- W1997552453 cites W1523420120 @default.
- W1997552453 cites W1543494855 @default.
- W1997552453 cites W1555380614 @default.
- W1997552453 cites W1565733046 @default.
- W1997552453 cites W1585567541 @default.
- W1997552453 cites W1589760452 @default.
- W1997552453 cites W1594715223 @default.
- W1997552453 cites W1863952384 @default.
- W1997552453 cites W1900384696 @default.
- W1997552453 cites W1908925937 @default.
- W1997552453 cites W1964759572 @default.
- W1997552453 cites W1965980379 @default.
- W1997552453 cites W1968478912 @default.
- W1997552453 cites W1968596886 @default.
- W1997552453 cites W1968639426 @default.
- W1997552453 cites W1969828445 @default.
- W1997552453 cites W1971963164 @default.
- W1997552453 cites W1973003441 @default.
- W1997552453 cites W1973558327 @default.
- W1997552453 cites W1974011377 @default.
- W1997552453 cites W1974535493 @default.
- W1997552453 cites W1974824274 @default.
- W1997552453 cites W1975107105 @default.
- W1997552453 cites W1975200361 @default.
- W1997552453 cites W1975917092 @default.
- W1997552453 cites W1977149491 @default.
- W1997552453 cites W1977570383 @default.
- W1997552453 cites W1978885168 @default.
- W1997552453 cites W1980129249 @default.
- W1997552453 cites W1982354147 @default.
- W1997552453 cites W1983313577 @default.
- W1997552453 cites W1983531330 @default.
- W1997552453 cites W1983557363 @default.
- W1997552453 cites W1984044963 @default.
- W1997552453 cites W1984432633 @default.
- W1997552453 cites W1986664250 @default.
- W1997552453 cites W1987074025 @default.
- W1997552453 cites W1991173530 @default.
- W1997552453 cites W1991425914 @default.
- W1997552453 cites W1993448456 @default.
- W1997552453 cites W1996180151 @default.
- W1997552453 cites W1996817722 @default.
- W1997552453 cites W2002102189 @default.
- W1997552453 cites W2003615702 @default.
- W1997552453 cites W2003972504 @default.
- W1997552453 cites W2005179225 @default.
- W1997552453 cites W2006059143 @default.
- W1997552453 cites W2007676805 @default.
- W1997552453 cites W2011904196 @default.
- W1997552453 cites W2014575600 @default.
- W1997552453 cites W2018029080 @default.
- W1997552453 cites W2018870179 @default.
- W1997552453 cites W2019416182 @default.
- W1997552453 cites W2020475548 @default.
- W1997552453 cites W2020628782 @default.
- W1997552453 cites W2021590473 @default.
- W1997552453 cites W2021724642 @default.
- W1997552453 cites W2021852515 @default.
- W1997552453 cites W2022982007 @default.
- W1997552453 cites W2024917525 @default.
- W1997552453 cites W2026084078 @default.
- W1997552453 cites W2028523997 @default.
- W1997552453 cites W2028613133 @default.
- W1997552453 cites W2030656771 @default.
- W1997552453 cites W2033857293 @default.
- W1997552453 cites W2033919747 @default.
- W1997552453 cites W2034307455 @default.
- W1997552453 cites W2037471205 @default.
- W1997552453 cites W2038143539 @default.
- W1997552453 cites W2041074604 @default.
- W1997552453 cites W2050660820 @default.
- W1997552453 cites W2052087115 @default.
- W1997552453 cites W2054812644 @default.
- W1997552453 cites W2055100675 @default.
- W1997552453 cites W2055574382 @default.
- W1997552453 cites W2056143910 @default.
- W1997552453 cites W2057415381 @default.
- W1997552453 cites W2061069622 @default.
- W1997552453 cites W2062264359 @default.
- W1997552453 cites W2062767834 @default.
- W1997552453 cites W2063487518 @default.
- W1997552453 cites W2067161476 @default.
- W1997552453 cites W2069546240 @default.
- W1997552453 cites W2070296004 @default.
- W1997552453 cites W2071455705 @default.
- W1997552453 cites W2073739021 @default.
- W1997552453 cites W2075612872 @default.
- W1997552453 cites W2075925586 @default.