FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997553458> ?p ?o ?g. }

• W1997553458 endingPage "69" @default.
• W1997553458 startingPage "57" @default.
• W1997553458 abstract "The paper summarizes literature data on the importance of oxidative stress as one of the pathogenetic mechanisms in Alzheimer's disease. The paper describes the main specific and nonspecific ways of reactive oxygen species generation in the course of the disease development. The effect of reactive oxygen species generated by the functional activity of cells, i.e. apoptosis and mitotic cycle, is shown. The role of the regulatory system of nodal cells is performed by phosphorylation/dephosphorylation process which is associated with intense phosphorylation of tau protein and mitosis-specific proteins. In Alzheimer's disease, the regulating function of peptidyl-prolyl isomerases in particular of Pin1 associated with maintaining a balanced state of phosphorylation/dephosphorylation processes is disturbed. Taking into consideration the multifactorial impairment of the cell cycle control, this process should be considered from the standpoint of the general state of metabolic processes, and oxidative stress has one of the key positions in aging. Obobshcheny literaturnye dannye o znachimosti okislitel'nogo stressa v kachestve odnogo iz patogeneticheskikh zven'ev bolezni Al'tsgeĭmera. Otrazheny osnovnye spetsificheskie i nespetsificheskie puti generatsii aktivnykh form kisloroda pri razvitii bolezni. Pokazano vliianie generiruemykh aktivnykh form kisloroda na funktsional'nuiu aktivnost' kletok – apoptoz i mitoticheskiĭ tsikl. Rol' uzlovoĭ reguliatornoĭ sistemy kletok pri étom vypolniaiut protsessy fosforilirovaniia/defosforilirovaniia, chto sopriazheno s intensivnym fosforilirovaniem belka tau, belkov, uchastvuiushchikh v mitoze. Pri bolezni Al'tsgeĭmera narushaetsia reguliruiushchaia funktsiia peptidil-prolilizomeraz, v chastnosti, Pin1, sviazannaia s podderzhaniem sbalansirovannogo sostoianiia protsessov fosforilirovaniia/defosforilirovaniia. Uchityvaia mnogofaktornost' narusheniia kontrolia kletochnogo tsikla, sleduet rassmatrivat' étot protsessa s pozitsiĭ obshchego sostoianiia metabolicheskikh protsessov, odnu iz kliuchevykh pozitsiĭ kotorykh pri starenii organizma zanimaet okislitel'nyĭ stress." @default.
• W1997553458 created "2016-06-24" @default.
• W1997553458 creator A5025230615 @default.
• W1997553458 creator A5049968393 @default.
• W1997553458 creator A5055717630 @default.
• W1997553458 creator A5068823081 @default.
• W1997553458 creator A5069813919 @default.
• W1997553458 date "2015-01-01" @default.
• W1997553458 modified "2023-10-16" @default.
• W1997553458 title "Oxidative stress and its effect on cells functional activity of Alzheimer's disease" @default.
• W1997553458 cites W1503983308 @default.
• W1997553458 cites W1539836937 @default.
• W1997553458 cites W1541944730 @default.
• W1997553458 cites W1584774790 @default.
• W1997553458 cites W1600934558 @default.
• W1997553458 cites W1602112568 @default.
• W1997553458 cites W1708325824 @default.
• W1997553458 cites W1731253253 @default.
• W1997553458 cites W1935951477 @default.
• W1997553458 cites W1965253637 @default.
• W1997553458 cites W1965310787 @default.
• W1997553458 cites W1965926538 @default.
• W1997553458 cites W1969209100 @default.
• W1997553458 cites W1970452111 @default.
• W1997553458 cites W1972114796 @default.
• W1997553458 cites W1972904318 @default.
• W1997553458 cites W1974036368 @default.
• W1997553458 cites W1975490572 @default.
• W1997553458 cites W1976513729 @default.
• W1997553458 cites W1978254707 @default.
• W1997553458 cites W1978907821 @default.
• W1997553458 cites W1984142578 @default.
• W1997553458 cites W1986958981 @default.
• W1997553458 cites W1987476077 @default.
• W1997553458 cites W1987679230 @default.
• W1997553458 cites W1987909503 @default.
• W1997553458 cites W1988107440 @default.
• W1997553458 cites W1989114735 @default.
• W1997553458 cites W1994235379 @default.
• W1997553458 cites W1996579240 @default.
• W1997553458 cites W1998282006 @default.
• W1997553458 cites W2001924139 @default.
• W1997553458 cites W2005322563 @default.
• W1997553458 cites W2005849137 @default.
• W1997553458 cites W2009882167 @default.
• W1997553458 cites W2019871046 @default.
• W1997553458 cites W2021740591 @default.
• W1997553458 cites W2025438577 @default.
• W1997553458 cites W2025869035 @default.
• W1997553458 cites W2031433969 @default.
• W1997553458 cites W2033379465 @default.
• W1997553458 cites W2035299293 @default.
• W1997553458 cites W2035506508 @default.
• W1997553458 cites W2035711542 @default.
• W1997553458 cites W2036098697 @default.
• W1997553458 cites W2036712586 @default.
• W1997553458 cites W2036755018 @default.
• W1997553458 cites W2036825042 @default.
• W1997553458 cites W2037116841 @default.
• W1997553458 cites W2039562082 @default.
• W1997553458 cites W2041985732 @default.
• W1997553458 cites W2045063195 @default.
• W1997553458 cites W2046452071 @default.
• W1997553458 cites W2047613132 @default.
• W1997553458 cites W2048289427 @default.
• W1997553458 cites W2049192526 @default.
• W1997553458 cites W2055675798 @default.
• W1997553458 cites W2055799551 @default.
• W1997553458 cites W2058747572 @default.
• W1997553458 cites W2061152334 @default.
• W1997553458 cites W2061500679 @default.
• W1997553458 cites W2062519141 @default.
• W1997553458 cites W2074059686 @default.
• W1997553458 cites W2080426159 @default.
• W1997553458 cites W2080623832 @default.
• W1997553458 cites W2083885993 @default.
• W1997553458 cites W2083894644 @default.
• W1997553458 cites W2084155803 @default.
• W1997553458 cites W2087807919 @default.
• W1997553458 cites W2087969945 @default.
• W1997553458 cites W2091665009 @default.
• W1997553458 cites W2091711919 @default.
• W1997553458 cites W2092108176 @default.
• W1997553458 cites W2093685823 @default.
• W1997553458 cites W2097389952 @default.
• W1997553458 cites W2105939406 @default.
• W1997553458 cites W2106406927 @default.
• W1997553458 cites W2110288122 @default.
• W1997553458 cites W2110464595 @default.
• W1997553458 cites W2112587738 @default.
• W1997553458 cites W2113046739 @default.
• W1997553458 cites W2114302599 @default.
• W1997553458 cites W2115978010 @default.
• W1997553458 cites W2116489922 @default.
• W1997553458 cites W2122456833 @default.
• W1997553458 cites W2123619340 @default.
• W1997553458 cites W2137841260 @default.
• W1997553458 cites W2140432027 @default.

• next