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- W1997557110 endingPage "2872" @default.
- W1997557110 startingPage "2859" @default.
- W1997557110 abstract "Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunction, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent biological processes contribute to plaque instability and the ultimate clinical sequelae of plaque rupture and life-threatening tissue ischemia. Administration of anti-LOX-1 antibodies inhibits atherosclerosis by decreasing these cellular events. Over the past decade, multiple drugs including naturally occurring antioxidants, statins, antiinflammatory agents, antihypertensive and antihyperglycemic drugs have been demonstrated to inhibit vascular LOX-1 expression and activity. Therefore, LOX-1 represents an attractive therapeutic target for the treatment of human atherosclerotic diseases. This review aims to integrate the current understanding of LOX-1 signaling, regulation of LOX-1 by vasculoprotective drugs, and the importance of LOX-1 in the pathogenesis of atherosclerosis." @default.
- W1997557110 created "2016-06-24" @default.
- W1997557110 creator A5009067006 @default.
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- W1997557110 creator A5048042168 @default.
- W1997557110 creator A5072381107 @default.
- W1997557110 creator A5075494494 @default.
- W1997557110 date "2012-11-03" @default.
- W1997557110 modified "2023-10-12" @default.
- W1997557110 title "LOX-1 in atherosclerosis: biological functions and pharmacological modifiers" @default.
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