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- W1997568788 abstract "• Microglial–neuronal interactions are critical in peripheral neuropathic pain. • The adoption of a reactive phenotype characterized by the surface expression of P2X4 receptors in spinal microglia is necessary. • P2X4R-p38-BDNF-KCC2 is the core signalling pathway. • Mediators of each component of the core pathway may represent therapeutic targets for novel analgesics. Microglia are key cellular mediators of plasticity in the spinal cord that drives the development and maintenance of pain hypersensitivity following peripheral nerve damage. An essential reactive microglial phenotype is characterized by induced expression of purinergic P2X4 receptors. Activation of these receptors initiates a core microglial-neuronal signalling pathway which through disinhibition transforms the output of dorsal horn neurons projecting to the brain pain networks. Here we describe recent advances in elucidating molecules that regulate key aspects of this core pathway, and opportunities for targeting critical signalling hubs to treat neuropathic pain." @default.
- W1997568788 created "2016-06-24" @default.
- W1997568788 creator A5072782296 @default.
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- W1997568788 date "2013-12-01" @default.
- W1997568788 modified "2023-09-24" @default.
- W1997568788 title "The known knowns of microglia–neuronal signalling in neuropathic pain" @default.
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- W1997568788 cites W1533386139 @default.
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- W1997568788 cites W1961955158 @default.
- W1997568788 cites W1969771733 @default.
- W1997568788 cites W1969889453 @default.
- W1997568788 cites W1970202520 @default.
- W1997568788 cites W1978269241 @default.
- W1997568788 cites W1979885252 @default.
- W1997568788 cites W1984332572 @default.
- W1997568788 cites W1988889092 @default.
- W1997568788 cites W1991386672 @default.
- W1997568788 cites W1995127502 @default.
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- W1997568788 doi "https://doi.org/10.1016/j.neulet.2013.08.037" @default.
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