FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997570880> ?p ?o ?g. }

• W1997570880 endingPage "237" @default.
• W1997570880 startingPage "227" @default.
• W1997570880 abstract "Previous investigations have indicated that the measurement of ω3 (peripheral-type benzodiazepine) binding site densities could be of widespread applicability in the localization and quantification of neural tissue damage in the central nervous system. In the first step of the present study, the suitability of this approach for the assessment of soman-induced brain damage was validated. Autoradiographic study revealed marked increases of ω3 site densities in several brain areas of convulsing rats 2 days after soman challenge. These increases were well-correlated with the pattern and the amplitude of neuropathological alterations due to soman and closely related to both glial reaction and macrophage invasion of the lesioned tissues. We then used this marker to assess, in mouse hippocampus, the neuroprotective activity against soman-induced brain damage of NBQX and TCP which are respective antagonists of non-NMDA and NMDA glutamatergic receptors. Injection of NBQX at 20 or 40 mg/kg 5 min prior to soman totally prevented the neuronal damage. Comparatively, TCP had neuroprotective efficacy when administered at 1 mg/kg 5 min prior to soman followed by a reinjection 1 h after. These results demonstrate that both NBQX and TCP afford a satisfactory neuroprotection against soman-induced brain damage. Since it is known that the neuropathology due to soman is closely seizure-related, the neuroprotective activities of NBQX and TCP are discussed in relation with the respective roles of non-NMDA and NMDA receptors in the onset and maintenance of soman-induced seizures." @default.
• W1997570880 created "2016-06-24" @default.
• W1997570880 creator A5003999761 @default.
• W1997570880 creator A5019246535 @default.
• W1997570880 creator A5019752270 @default.
• W1997570880 creator A5020052353 @default.
• W1997570880 creator A5046578717 @default.
• W1997570880 creator A5074575678 @default.
• W1997570880 creator A5088128244 @default.
• W1997570880 date "1993-08-01" @default.
• W1997570880 modified "2023-09-23" @default.
• W1997570880 title "Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an ω3 site ligand" @default.
• W1997570880 cites W1489253223 @default.
• W1997570880 cites W1775749144 @default.
• W1997570880 cites W1912564681 @default.
• W1997570880 cites W1965509912 @default.
• W1997570880 cites W1969047674 @default.
• W1997570880 cites W1985554234 @default.
• W1997570880 cites W1986607212 @default.
• W1997570880 cites W2002175811 @default.
• W1997570880 cites W2008706843 @default.
• W1997570880 cites W2009304543 @default.
• W1997570880 cites W2023396428 @default.
• W1997570880 cites W2023811880 @default.
• W1997570880 cites W2029515915 @default.
• W1997570880 cites W2042969415 @default.
• W1997570880 cites W2045415882 @default.
• W1997570880 cites W2051237723 @default.
• W1997570880 cites W2051875864 @default.
• W1997570880 cites W2055749276 @default.
• W1997570880 cites W2068649586 @default.
• W1997570880 cites W2073907109 @default.
• W1997570880 cites W2075150500 @default.
• W1997570880 cites W2081787790 @default.
• W1997570880 cites W2082480382 @default.
• W1997570880 cites W2089258031 @default.
• W1997570880 cites W2092459398 @default.
• W1997570880 cites W2093694387 @default.
• W1997570880 cites W2094249835 @default.
• W1997570880 cites W2094749887 @default.
• W1997570880 cites W2095089841 @default.
• W1997570880 cites W2095358033 @default.
• W1997570880 cites W2147064870 @default.
• W1997570880 cites W2167825748 @default.
• W1997570880 cites W4319053766 @default.
• W1997570880 doi "https://doi.org/10.1016/0006-8993(93)91270-3" @default.
• W1997570880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8397049" @default.
• W1997570880 hasPublicationYear "1993" @default.
• W1997570880 type Work @default.
• W1997570880 sameAs 1997570880 @default.
• W1997570880 citedByCount "59" @default.
• W1997570880 countsByYear W19975708802012 @default.
• W1997570880 countsByYear W19975708802013 @default.
• W1997570880 countsByYear W19975708802014 @default.
• W1997570880 countsByYear W19975708802015 @default.
• W1997570880 countsByYear W19975708802016 @default.
• W1997570880 countsByYear W19975708802018 @default.
• W1997570880 countsByYear W19975708802020 @default.
• W1997570880 countsByYear W19975708802021 @default.
• W1997570880 crossrefType "journal-article" @default.
• W1997570880 hasAuthorship W1997570880A5003999761 @default.
• W1997570880 hasAuthorship W1997570880A5019246535 @default.
• W1997570880 hasAuthorship W1997570880A5019752270 @default.
• W1997570880 hasAuthorship W1997570880A5020052353 @default.
• W1997570880 hasAuthorship W1997570880A5046578717 @default.
• W1997570880 hasAuthorship W1997570880A5074575678 @default.
• W1997570880 hasAuthorship W1997570880A5088128244 @default.
• W1997570880 hasConcept C148762608 @default.
• W1997570880 hasConcept C160268369 @default.
• W1997570880 hasConcept C169760540 @default.
• W1997570880 hasConcept C170493617 @default.
• W1997570880 hasConcept C181199279 @default.
• W1997570880 hasConcept C185592680 @default.
• W1997570880 hasConcept C25498285 @default.
• W1997570880 hasConcept C2778816929 @default.
• W1997570880 hasConcept C2780076171 @default.
• W1997570880 hasConcept C2780266723 @default.
• W1997570880 hasConcept C2781012912 @default.
• W1997570880 hasConcept C2781161787 @default.
• W1997570880 hasConcept C2781458332 @default.
• W1997570880 hasConcept C42219234 @default.
• W1997570880 hasConcept C55493867 @default.
• W1997570880 hasConcept C61174792 @default.
• W1997570880 hasConcept C67018056 @default.
• W1997570880 hasConcept C71924100 @default.
• W1997570880 hasConcept C86803240 @default.
• W1997570880 hasConcept C98274493 @default.
• W1997570880 hasConceptScore W1997570880C148762608 @default.
• W1997570880 hasConceptScore W1997570880C160268369 @default.
• W1997570880 hasConceptScore W1997570880C169760540 @default.
• W1997570880 hasConceptScore W1997570880C170493617 @default.
• W1997570880 hasConceptScore W1997570880C181199279 @default.
• W1997570880 hasConceptScore W1997570880C185592680 @default.
• W1997570880 hasConceptScore W1997570880C25498285 @default.
• W1997570880 hasConceptScore W1997570880C2778816929 @default.
• W1997570880 hasConceptScore W1997570880C2780076171 @default.
• W1997570880 hasConceptScore W1997570880C2780266723 @default.
• W1997570880 hasConceptScore W1997570880C2781012912 @default.

• next