Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997572015> ?p ?o ?g. }
- W1997572015 endingPage "130" @default.
- W1997572015 startingPage "117" @default.
- W1997572015 abstract "A novel technique involving hypertonic stress causes membrane ‘blebbing’ of the Xenopus oocyte and the shedding of plasma membrane vesicles (PMVs). Confocal fluorescence microscopy, immunocytochemistry and electron microscopy indicate that blebs and PMVs lack cortical cytoskeleton and are deficient in cytoskeleton proteins and devoid of microvilli. Patch recordings from PMVs consistently reveal mechanically gated (MG) channel activity. The MG channels display the same single‐channel conductance as control recordings but differ in terms of reduced mechanosensitivity and adaptation to sustained stimulation. Whole PMV recordings show rapid and reversible activation of mechanosensitive currents in response to pressure pulses. The maximal currents activated in PMVs are consistent with MG channel activity recorded in patches. The discrepancy between MG channel activity recorded in whole PMVs and oocytes most probably reflects their different membrane geometry and ability to develop activating bilayer tensions. We propose that membrane blebbing, which is known to occur under specific physiological and pathological conditions (e.g. mitosis and apoptosis), may increase mechanosensitivity independently of the intrinsic properties of membrane proteins." @default.
- W1997572015 created "2016-06-24" @default.
- W1997572015 creator A5008093964 @default.
- W1997572015 creator A5026643506 @default.
- W1997572015 creator A5033515303 @default.
- W1997572015 creator A5053438808 @default.
- W1997572015 creator A5056763730 @default.
- W1997572015 date "2000-02-01" @default.
- W1997572015 modified "2023-10-18" @default.
- W1997572015 title "Mechanically gated channel activity in cytoskeleton‐deficient plasma membrane blebs and vesicles from <i>Xenopus</i> oocytes" @default.
- W1997572015 cites W129891204 @default.
- W1997572015 cites W1805242201 @default.
- W1997572015 cites W1926854487 @default.
- W1997572015 cites W1969707854 @default.
- W1997572015 cites W1978599751 @default.
- W1997572015 cites W1990859310 @default.
- W1997572015 cites W1992420486 @default.
- W1997572015 cites W1993142984 @default.
- W1997572015 cites W1997190969 @default.
- W1997572015 cites W1997511216 @default.
- W1997572015 cites W1999411716 @default.
- W1997572015 cites W2007665141 @default.
- W1997572015 cites W2009667219 @default.
- W1997572015 cites W2013306039 @default.
- W1997572015 cites W2015249790 @default.
- W1997572015 cites W2015426350 @default.
- W1997572015 cites W2020149988 @default.
- W1997572015 cites W2025720625 @default.
- W1997572015 cites W2031421701 @default.
- W1997572015 cites W2032598891 @default.
- W1997572015 cites W2033980199 @default.
- W1997572015 cites W2042415724 @default.
- W1997572015 cites W2045286669 @default.
- W1997572015 cites W2052853635 @default.
- W1997572015 cites W2073149428 @default.
- W1997572015 cites W2074731300 @default.
- W1997572015 cites W2075772363 @default.
- W1997572015 cites W2079031364 @default.
- W1997572015 cites W2093861837 @default.
- W1997572015 cites W2095544165 @default.
- W1997572015 cites W2107450906 @default.
- W1997572015 cites W2107600850 @default.
- W1997572015 cites W2119595362 @default.
- W1997572015 cites W2125942201 @default.
- W1997572015 cites W2137530264 @default.
- W1997572015 cites W2154939910 @default.
- W1997572015 cites W2157194890 @default.
- W1997572015 cites W2161897058 @default.
- W1997572015 cites W2404260053 @default.
- W1997572015 cites W2409505590 @default.
- W1997572015 cites W2460381293 @default.
- W1997572015 doi "https://doi.org/10.1111/j.1469-7793.2000.t01-1-00117.x" @default.
- W1997572015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269789" @default.
- W1997572015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10673548" @default.
- W1997572015 hasPublicationYear "2000" @default.
- W1997572015 type Work @default.
- W1997572015 sameAs 1997572015 @default.
- W1997572015 citedByCount "90" @default.
- W1997572015 countsByYear W19975720152012 @default.
- W1997572015 countsByYear W19975720152013 @default.
- W1997572015 countsByYear W19975720152014 @default.
- W1997572015 countsByYear W19975720152015 @default.
- W1997572015 countsByYear W19975720152016 @default.
- W1997572015 countsByYear W19975720152017 @default.
- W1997572015 countsByYear W19975720152018 @default.
- W1997572015 countsByYear W19975720152019 @default.
- W1997572015 countsByYear W19975720152020 @default.
- W1997572015 countsByYear W19975720152022 @default.
- W1997572015 crossrefType "journal-article" @default.
- W1997572015 hasAuthorship W1997572015A5008093964 @default.
- W1997572015 hasAuthorship W1997572015A5026643506 @default.
- W1997572015 hasAuthorship W1997572015A5033515303 @default.
- W1997572015 hasAuthorship W1997572015A5053438808 @default.
- W1997572015 hasAuthorship W1997572015A5056763730 @default.
- W1997572015 hasBestOaLocation W19975720151 @default.
- W1997572015 hasConcept C104317684 @default.
- W1997572015 hasConcept C117277713 @default.
- W1997572015 hasConcept C12554922 @default.
- W1997572015 hasConcept C130316041 @default.
- W1997572015 hasConcept C134018914 @default.
- W1997572015 hasConcept C142669718 @default.
- W1997572015 hasConcept C1491633281 @default.
- W1997572015 hasConcept C170493617 @default.
- W1997572015 hasConcept C185592680 @default.
- W1997572015 hasConcept C2779535977 @default.
- W1997572015 hasConcept C35866371 @default.
- W1997572015 hasConcept C4001165 @default.
- W1997572015 hasConcept C41625074 @default.
- W1997572015 hasConcept C50254741 @default.
- W1997572015 hasConcept C55493867 @default.
- W1997572015 hasConcept C86803240 @default.
- W1997572015 hasConcept C95444343 @default.
- W1997572015 hasConceptScore W1997572015C104317684 @default.
- W1997572015 hasConceptScore W1997572015C117277713 @default.
- W1997572015 hasConceptScore W1997572015C12554922 @default.
- W1997572015 hasConceptScore W1997572015C130316041 @default.
- W1997572015 hasConceptScore W1997572015C134018914 @default.
- W1997572015 hasConceptScore W1997572015C142669718 @default.