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• W1997577145 abstract "This study examines the isoform-specific effects of short-term hindlimb suspension (HS) on the Na,K-ATPase in rat soleus muscle. Rats were exposed to 24–72 h of HS and we analyzed the consequences on soleus muscle mass and contractile parameters; excitability and the resting membrane potential (RMP) of muscle fibers; the electrogenic activity, protein, and mRNA content of the α 1 and α 2 Na,K-ATPase; the functional activity and plasma membrane localization of the α 2 Na,K-ATPase. Our results indicate that 24–72 h of HS specifically decreases the electrogenic activity of the Na,K-ATPase α 2 isozyme and the RMP of soleus muscle fibers. This decrease occurs prior to muscle atrophy or any change in contractile parameters. The α 2 mRNA and protein content increased after 24 h of HS and returned to initial levels at 72 h; however, even the increased content was not able to restore α 2 enzyme activity in the disused soleus muscle. There was no change in the membrane localization of α 2 Na,K-ATPase. The α 1 Na,K-ATPase electrogenic activity, protein and mRNA content did not change. Our findings suggest that skeletal muscle use is absolutely required for α 2 Na,K-ATPase transport activity and provide the first evidence that Na,K-ATPase alterations precede HS-induced muscle atrophy." @default.
• W1997577145 created "2016-06-24" @default.
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• W1997577145 date "2015-01-01" @default.
• W1997577145 modified "2023-10-14" @default.
• W1997577145 title "Isoform-Specific Na,K-ATPase Alterations Precede Disuse-Induced Atrophy of Rat Soleus Muscle" @default.
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• W1997577145 doi "https://doi.org/10.1155/2015/720172" @default.
• W1997577145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309216" @default.
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