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- W1997580019 abstract "The anti-HIV activity of nucleoside analogues is highly related to their substrate specificity for cellular and viral kinase and, as triphosphate, for HIV-RT. A series of phosphoramidate d4T derivatives have been synthesized and evaluated as substrates for HIV-1 RT, and also tested for their in vitro anti-HIV activity. Compounds 2 and 4 are able to inhibit HIV-1 replication to the same extent as d4T and d4TMP in MT-4 cells as well as in CEM/0 cells and CEM/TK−cells. The data suggests that these phosphoramidates are hydrolysed to d4T before exerting their antiviral activity." @default.
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- W1997580019 date "2012-01-01" @default.
- W1997580019 modified "2023-10-09" @default.
- W1997580019 title "Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators" @default.
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- W1997580019 doi "https://doi.org/10.1039/c1ob06214j" @default.
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