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- W1997581567 abstract "Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed." @default.
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- W1997581567 date "2011-08-01" @default.
- W1997581567 modified "2023-10-12" @default.
- W1997581567 title "Folate-decorated nanogels for targeted therapy of ovarian cancer" @default.
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- W1997581567 doi "https://doi.org/10.1016/j.biomaterials.2011.04.006" @default.
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