FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997583255> ?p ?o ?g. }

• W1997583255 endingPage "2140" @default.
• W1997583255 startingPage "2136" @default.
• W1997583255 abstract "Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such factors, we compared the frequencies of SNPs among PCa patients who were defined as having either more aggressive or less aggressive disease in four populations examined in the Genetic Markers of Susceptibility (CGEMS) study performed by the National Cancer Institute. SNPs showing possible associations with disease severity were further evaluated in an additional three independent study populations from the United States and Sweden. In total, we studied 4,829 and 12,205 patients with more and less aggressive disease, respectively. We found that the frequency of the TT genotype of SNP rs4054823 at 17p12 was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied, with an overall P value of 2.1 × 10 −8 under a recessive model, exceeding the conservative genome-wide significance level. The difference in frequency was largest between patients with high-grade, non–organ-confined disease compared with those with low-grade, organ-confined disease. This study demonstrates that inherited variants predisposing to aggressive but not indolent PCa exist in the genome, and suggests that the clinical potential of such variants as potential early markers for risk of aggressive PCa should be evaluated." @default.
• W1997583255 created "2016-06-24" @default.
• W1997583255 creator A5005146231 @default.
• W1997583255 creator A5009821731 @default.
• W1997583255 creator A5010401322 @default.
• W1997583255 creator A5018331985 @default.
• W1997583255 creator A5021982213 @default.
• W1997583255 creator A5022649819 @default.
• W1997583255 creator A5023337609 @default.
• W1997583255 creator A5027914604 @default.
• W1997583255 creator A5031205173 @default.
• W1997583255 creator A5032713796 @default.
• W1997583255 creator A5033731052 @default.
• W1997583255 creator A5036671821 @default.
• W1997583255 creator A5036702636 @default.
• W1997583255 creator A5037735093 @default.
• W1997583255 creator A5048268037 @default.
• W1997583255 creator A5064981403 @default.
• W1997583255 creator A5068348417 @default.
• W1997583255 creator A5072103440 @default.
• W1997583255 creator A5075913396 @default.
• W1997583255 creator A5080927178 @default.
• W1997583255 date "2010-01-11" @default.
• W1997583255 modified "2023-10-15" @default.
• W1997583255 title "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer" @default.
• W1997583255 cites W1974326568 @default.
• W1997583255 cites W1977546001 @default.
• W1997583255 cites W1985993090 @default.
• W1997583255 cites W1995404520 @default.
• W1997583255 cites W2000823134 @default.
• W1997583255 cites W2001816262 @default.
• W1997583255 cites W2015449882 @default.
• W1997583255 cites W2023455695 @default.
• W1997583255 cites W2031466179 @default.
• W1997583255 cites W2031960691 @default.
• W1997583255 cites W2037119446 @default.
• W1997583255 cites W2044785539 @default.
• W1997583255 cites W2044916117 @default.
• W1997583255 cites W2045186357 @default.
• W1997583255 cites W2047200356 @default.
• W1997583255 cites W2064061478 @default.
• W1997583255 cites W2064950402 @default.
• W1997583255 cites W2065218625 @default.
• W1997583255 cites W2079585801 @default.
• W1997583255 cites W2083043726 @default.
• W1997583255 cites W2093743418 @default.
• W1997583255 cites W2095761465 @default.
• W1997583255 cites W2096289472 @default.
• W1997583255 cites W2101995865 @default.
• W1997583255 cites W2102091298 @default.
• W1997583255 cites W2118856443 @default.
• W1997583255 cites W2122296279 @default.
• W1997583255 cites W2131778503 @default.
• W1997583255 cites W2131872372 @default.
• W1997583255 cites W2132281105 @default.
• W1997583255 cites W2132528779 @default.
• W1997583255 cites W2133234163 @default.
• W1997583255 cites W2135456872 @default.
• W1997583255 cites W2144694756 @default.
• W1997583255 cites W2145657085 @default.
• W1997583255 cites W2147238961 @default.
• W1997583255 cites W2154638022 @default.
• W1997583255 cites W2157043398 @default.
• W1997583255 cites W2159972811 @default.
• W1997583255 cites W2164698082 @default.
• W1997583255 cites W2164716330 @default.
• W1997583255 cites W2171682260 @default.
• W1997583255 doi "https://doi.org/10.1073/pnas.0914061107" @default.
• W1997583255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836698" @default.
• W1997583255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20080650" @default.
• W1997583255 hasPublicationYear "2010" @default.
• W1997583255 type Work @default.
• W1997583255 sameAs 1997583255 @default.
• W1997583255 citedByCount "108" @default.
• W1997583255 countsByYear W19975832552012 @default.
• W1997583255 countsByYear W19975832552013 @default.
• W1997583255 countsByYear W19975832552014 @default.
• W1997583255 countsByYear W19975832552015 @default.
• W1997583255 countsByYear W19975832552016 @default.
• W1997583255 countsByYear W19975832552017 @default.
• W1997583255 countsByYear W19975832552018 @default.
• W1997583255 countsByYear W19975832552019 @default.
• W1997583255 countsByYear W19975832552020 @default.
• W1997583255 countsByYear W19975832552021 @default.
• W1997583255 countsByYear W19975832552022 @default.
• W1997583255 countsByYear W19975832552023 @default.
• W1997583255 crossrefType "journal-article" @default.
• W1997583255 hasAuthorship W1997583255A5005146231 @default.
• W1997583255 hasAuthorship W1997583255A5009821731 @default.
• W1997583255 hasAuthorship W1997583255A5010401322 @default.
• W1997583255 hasAuthorship W1997583255A5018331985 @default.
• W1997583255 hasAuthorship W1997583255A5021982213 @default.
• W1997583255 hasAuthorship W1997583255A5022649819 @default.
• W1997583255 hasAuthorship W1997583255A5023337609 @default.
• W1997583255 hasAuthorship W1997583255A5027914604 @default.
• W1997583255 hasAuthorship W1997583255A5031205173 @default.
• W1997583255 hasAuthorship W1997583255A5032713796 @default.
• W1997583255 hasAuthorship W1997583255A5033731052 @default.

• next