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- W1997587411 abstract "Chemical sympathectomy was achieved in guinea pig trachea 24 hr after a single dose of 50 mg/kg (i.v. or i.p.) 6-hydroxydopamine (6-OHDA). This was shown by (a) the dissapearance of fluorescent nerve terminals (b) decreased uptake-with-retention of radioactivity following incubation in (−)-3H-noradrenaline (50 nM) and (c) the supersensitive response of the isolated tracheal chain preparation to noradrenaline. The susceptibility of the adrenergic nerve terminals in the lung of 6-OHDA resembled that of trachea, in that complete dissapearance of fluorescent nerve terminals was achieved with the above doses, whereas doses higher than 100 mg/kg were required to produce this in heart and iris. Chronic treatment of guinea pigs with guanethidine (25 or 30 mg/kg daily by i.p. injection for up to 6 weeks) did not produce destruction of adrenergic nerves in peripheral tissues." @default.
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- W1997587411 date "1974-10-01" @default.
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- W1997587411 title "The effects of 6-hydroxydopamine and guanethidine on peripheral adrenergic nerves in the guinea pig" @default.
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- W1997587411 doi "https://doi.org/10.1016/0014-2999(74)90277-5" @default.
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