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- W1997587779 endingPage "830" @default.
- W1997587779 startingPage "814" @default.
- W1997587779 abstract "Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. Inward currents arising from slow muscarinic transmission were characterized. These currents contribute to the B31/B32 depolarization. Their slow activation kinetics contribute to the delay preceding B31/B32 activity. After the delay, inward currents affect B31/B32 in the context of two endogenous inactivating outward currents: a delayed rectifier K + current ( I K-V ) and an A-type K + current ( I K-A ), as well as a high-threshold noninactivating outward current ( I maintained ). Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that I K-V and I K-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed." @default.
- W1997587779 created "2016-06-24" @default.
- W1997587779 creator A5000793201 @default.
- W1997587779 creator A5022914884 @default.
- W1997587779 creator A5031401864 @default.
- W1997587779 creator A5034877968 @default.
- W1997587779 creator A5055007664 @default.
- W1997587779 date "2008-02-01" @default.
- W1997587779 modified "2023-09-25" @default.
- W1997587779 title "Currents Contributing to Decision Making in Neurons B31/B32 of<i>Aplysia</i>" @default.
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