FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997588451> ?p ?o ?g. }

• W1997588451 endingPage "234" @default.
• W1997588451 startingPage "222" @default.
• W1997588451 abstract "A short-term animal bioassay was used to assess the toxicity of occupational dusts. We quantified pulmonary responses in hamsters exposed to granite (12% quartz) and talc (quartz and asbestos-free) dust collected from worksites. Personal samples collected on workers showed similar quartz content and particle-size distributions to the high-volume samples collected for bioassays, thus demonstrating that the particulates were representative of worker exposure. We measured biochemical and cellular indicators of injury in bronchoalveolar lavage fluid (BAL) of animals exposed to dust suspensions by intra-tracheal instillation. The assays measured release of cytoplasmic and lysosomal enzymes into the cell-free supernatant of BAL; levels of albumin and red blood cells; changes in macrophage and polymorphonuclear neutrophil cell numbers; and in situ macrophage phagocytosis. Dose-response (0.15, 0.75, and 3.75 mg/100 g body wt) and time-course (1-14 days postexposure) studies were performed. One day after exposure, both talc and granite dust resulted in elevated enzyme levels, pulmonary edema, and increased cell numbers in BAL. Macrophage phagocytosis was also inhibited. Based on earlier studies, response levels were either intermediate between nontoxic iron oxide and toxic alpha-quartz or comparable with alpha-quartz. The response to granite dust diminished fairly rapidly over time. By contrast, after talc exposure, there was a more persistent elevation in enzyme levels, and macrophage phagocytosis remained depressed. These results indicate that, when a similar mass was deposited in the lungs, talc caused more lung injury than did granite. Better estimates of exposure-dose relationships in talc and granite workers as well as longer-term animal studies are required to evaluate the harmfulness of these work environments at present-day exposure levels." @default.
• W1997588451 created "2016-06-24" @default.
• W1997588451 creator A5011723140 @default.
• W1997588451 creator A5012656746 @default.
• W1997588451 creator A5016675740 @default.
• W1997588451 creator A5043685328 @default.
• W1997588451 creator A5054848999 @default.
• W1997588451 creator A5080399997 @default.
• W1997588451 date "1987-02-01" @default.
• W1997588451 modified "2023-10-05" @default.
• W1997588451 title "The pulmonary toxicity of talc and granite dust as estimated from an in vivo hamster bioassay" @default.
• W1997588451 cites W144352246 @default.
• W1997588451 cites W1573196340 @default.
• W1997588451 cites W1657147564 @default.
• W1997588451 cites W1957734831 @default.
• W1997588451 cites W1976100298 @default.
• W1997588451 cites W1982390389 @default.
• W1997588451 cites W1989635101 @default.
• W1997588451 cites W1991915263 @default.
• W1997588451 cites W2004813039 @default.
• W1997588451 cites W2005161116 @default.
• W1997588451 cites W2019858986 @default.
• W1997588451 cites W2023266043 @default.
• W1997588451 cites W2024546830 @default.
• W1997588451 cites W2064415136 @default.
• W1997588451 cites W2067303957 @default.
• W1997588451 cites W2073721928 @default.
• W1997588451 cites W2076067075 @default.
• W1997588451 cites W2086370773 @default.
• W1997588451 cites W2097100175 @default.
• W1997588451 cites W2101173699 @default.
• W1997588451 cites W2131296305 @default.
• W1997588451 cites W2137562683 @default.
• W1997588451 cites W2320205052 @default.
• W1997588451 cites W2327762734 @default.
• W1997588451 cites W2333179817 @default.
• W1997588451 cites W2411164904 @default.
• W1997588451 cites W2416580895 @default.
• W1997588451 cites W3154367256 @default.
• W1997588451 cites W4321061168 @default.
• W1997588451 doi "https://doi.org/10.1016/0041-008x(87)90284-5" @default.
• W1997588451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3029896" @default.
• W1997588451 hasPublicationYear "1987" @default.
• W1997588451 type Work @default.
• W1997588451 sameAs 1997588451 @default.
• W1997588451 citedByCount "32" @default.
• W1997588451 countsByYear W19975884512012 @default.
• W1997588451 countsByYear W19975884512013 @default.
• W1997588451 countsByYear W19975884512015 @default.
• W1997588451 countsByYear W19975884512017 @default.
• W1997588451 countsByYear W19975884512019 @default.
• W1997588451 countsByYear W19975884512020 @default.
• W1997588451 countsByYear W19975884512021 @default.
• W1997588451 countsByYear W19975884512022 @default.
• W1997588451 countsByYear W19975884512023 @default.
• W1997588451 crossrefType "journal-article" @default.
• W1997588451 hasAuthorship W1997588451A5011723140 @default.
• W1997588451 hasAuthorship W1997588451A5012656746 @default.
• W1997588451 hasAuthorship W1997588451A5016675740 @default.
• W1997588451 hasAuthorship W1997588451A5043685328 @default.
• W1997588451 hasAuthorship W1997588451A5054848999 @default.
• W1997588451 hasAuthorship W1997588451A5080399997 @default.
• W1997588451 hasConcept C104488531 @default.
• W1997588451 hasConcept C126322002 @default.
• W1997588451 hasConcept C151730666 @default.
• W1997588451 hasConcept C160448771 @default.
• W1997588451 hasConcept C16685009 @default.
• W1997588451 hasConcept C185592680 @default.
• W1997588451 hasConcept C191897082 @default.
• W1997588451 hasConcept C192562407 @default.
• W1997588451 hasConcept C202751555 @default.
• W1997588451 hasConcept C203014093 @default.
• W1997588451 hasConcept C2777714996 @default.
• W1997588451 hasConcept C2777961210 @default.
• W1997588451 hasConcept C2778012055 @default.
• W1997588451 hasConcept C2778575167 @default.
• W1997588451 hasConcept C2779244956 @default.
• W1997588451 hasConcept C2779979586 @default.
• W1997588451 hasConcept C2781047374 @default.
• W1997588451 hasConcept C29730261 @default.
• W1997588451 hasConcept C510490043 @default.
• W1997588451 hasConcept C54355233 @default.
• W1997588451 hasConcept C55493867 @default.
• W1997588451 hasConcept C71924100 @default.
• W1997588451 hasConcept C86803240 @default.
• W1997588451 hasConceptScore W1997588451C104488531 @default.
• W1997588451 hasConceptScore W1997588451C126322002 @default.
• W1997588451 hasConceptScore W1997588451C151730666 @default.
• W1997588451 hasConceptScore W1997588451C160448771 @default.
• W1997588451 hasConceptScore W1997588451C16685009 @default.
• W1997588451 hasConceptScore W1997588451C185592680 @default.
• W1997588451 hasConceptScore W1997588451C191897082 @default.
• W1997588451 hasConceptScore W1997588451C192562407 @default.
• W1997588451 hasConceptScore W1997588451C202751555 @default.
• W1997588451 hasConceptScore W1997588451C203014093 @default.
• W1997588451 hasConceptScore W1997588451C2777714996 @default.
• W1997588451 hasConceptScore W1997588451C2777961210 @default.
• W1997588451 hasConceptScore W1997588451C2778012055 @default.

• next