Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997604869> ?p ?o ?g. }
- W1997604869 abstract "Although RAD52 plays a critical role in the initiation of homologous recombination (HR) by facilitating the replacement of RPA with RAD51, the mechanism controlling RAD52 remains elusive. Here, we show that Bag101, a factor implicated in proteasome functioning, regulates RAD52 protein levels and subsequent HR. LC-MS/MS analysis identified Bag101 which binds to Rad22, the fission yeast homologue of RAD52. Bag101 reduced HR frequency through its overexpression and conversely, HR frequencies were enhanced when it was deleted. Consistent with this observation, Rad22 protein levels was reduced in cells where bag101 was overexpressed even when Rad22 transcription was up-regulated, suggesting the operation of proteasome-mediated Rad22 degradation. Indeed, Rad22 protein levels were stabilized in proteasome mutants. Rad22 physically interacted with the BAG domain of Bag101, and a lack of this domain enhanced HR frequency. Similarly, radiation exposure triggered the dissociation of these proteins so that Rad22 was stabilized and able to enhance HR." @default.
- W1997604869 created "2016-06-24" @default.
- W1997604869 creator A5004307987 @default.
- W1997604869 creator A5005243857 @default.
- W1997604869 creator A5011865780 @default.
- W1997604869 creator A5016280663 @default.
- W1997604869 creator A5024186970 @default.
- W1997604869 creator A5056826583 @default.
- W1997604869 creator A5059971847 @default.
- W1997604869 creator A5066590781 @default.
- W1997604869 creator A5081550907 @default.
- W1997604869 creator A5084940370 @default.
- W1997604869 date "2013-06-19" @default.
- W1997604869 modified "2023-09-27" @default.
- W1997604869 title "The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination" @default.
- W1997604869 cites W1604305208 @default.
- W1997604869 cites W1832288685 @default.
- W1997604869 cites W1926322311 @default.
- W1997604869 cites W1930722859 @default.
- W1997604869 cites W1963798045 @default.
- W1997604869 cites W1965278267 @default.
- W1997604869 cites W1966044006 @default.
- W1997604869 cites W1973721031 @default.
- W1997604869 cites W1980350538 @default.
- W1997604869 cites W1985245436 @default.
- W1997604869 cites W1991617089 @default.
- W1997604869 cites W1994857104 @default.
- W1997604869 cites W2005814109 @default.
- W1997604869 cites W2022100127 @default.
- W1997604869 cites W2022912676 @default.
- W1997604869 cites W2025612803 @default.
- W1997604869 cites W2028138760 @default.
- W1997604869 cites W2032878080 @default.
- W1997604869 cites W2035994249 @default.
- W1997604869 cites W2037233550 @default.
- W1997604869 cites W2040426118 @default.
- W1997604869 cites W2041929141 @default.
- W1997604869 cites W2045597126 @default.
- W1997604869 cites W2052137750 @default.
- W1997604869 cites W2063277693 @default.
- W1997604869 cites W2067463001 @default.
- W1997604869 cites W2067618383 @default.
- W1997604869 cites W2069757035 @default.
- W1997604869 cites W2072592780 @default.
- W1997604869 cites W2073991273 @default.
- W1997604869 cites W2078030859 @default.
- W1997604869 cites W2083081815 @default.
- W1997604869 cites W2115988944 @default.
- W1997604869 cites W2126492332 @default.
- W1997604869 cites W2140886363 @default.
- W1997604869 cites W2144550200 @default.
- W1997604869 cites W2158482235 @default.
- W1997604869 cites W2219833176 @default.
- W1997604869 doi "https://doi.org/10.1038/srep02022" @default.
- W1997604869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3685826" @default.
- W1997604869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23779158" @default.
- W1997604869 hasPublicationYear "2013" @default.
- W1997604869 type Work @default.
- W1997604869 sameAs 1997604869 @default.
- W1997604869 citedByCount "6" @default.
- W1997604869 countsByYear W19976048692013 @default.
- W1997604869 countsByYear W19976048692014 @default.
- W1997604869 countsByYear W19976048692016 @default.
- W1997604869 countsByYear W19976048692017 @default.
- W1997604869 countsByYear W19976048692020 @default.
- W1997604869 crossrefType "journal-article" @default.
- W1997604869 hasAuthorship W1997604869A5004307987 @default.
- W1997604869 hasAuthorship W1997604869A5005243857 @default.
- W1997604869 hasAuthorship W1997604869A5011865780 @default.
- W1997604869 hasAuthorship W1997604869A5016280663 @default.
- W1997604869 hasAuthorship W1997604869A5024186970 @default.
- W1997604869 hasAuthorship W1997604869A5056826583 @default.
- W1997604869 hasAuthorship W1997604869A5059971847 @default.
- W1997604869 hasAuthorship W1997604869A5066590781 @default.
- W1997604869 hasAuthorship W1997604869A5081550907 @default.
- W1997604869 hasAuthorship W1997604869A5084940370 @default.
- W1997604869 hasBestOaLocation W19976048691 @default.
- W1997604869 hasConcept C102744134 @default.
- W1997604869 hasConcept C104317684 @default.
- W1997604869 hasConcept C143065580 @default.
- W1997604869 hasConcept C185592680 @default.
- W1997604869 hasConcept C27740335 @default.
- W1997604869 hasConcept C2776630724 @default.
- W1997604869 hasConcept C2779012473 @default.
- W1997604869 hasConcept C54355233 @default.
- W1997604869 hasConcept C64894306 @default.
- W1997604869 hasConcept C86339819 @default.
- W1997604869 hasConcept C86803240 @default.
- W1997604869 hasConcept C95444343 @default.
- W1997604869 hasConceptScore W1997604869C102744134 @default.
- W1997604869 hasConceptScore W1997604869C104317684 @default.
- W1997604869 hasConceptScore W1997604869C143065580 @default.
- W1997604869 hasConceptScore W1997604869C185592680 @default.
- W1997604869 hasConceptScore W1997604869C27740335 @default.
- W1997604869 hasConceptScore W1997604869C2776630724 @default.
- W1997604869 hasConceptScore W1997604869C2779012473 @default.
- W1997604869 hasConceptScore W1997604869C54355233 @default.
- W1997604869 hasConceptScore W1997604869C64894306 @default.
- W1997604869 hasConceptScore W1997604869C86339819 @default.
- W1997604869 hasConceptScore W1997604869C86803240 @default.