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• W1997614344 abstract "Modification of the P(1)' substituent of macrocyclic matrix metalloproteinase (MMP) inhibitors provided compounds that are selective for inhibition of tumor necrosis factor-alpha converting enzyme (TACE) over MMP-1 and MMP-2. Several analogues potently inhibited the release of TNF-alpha in a THP-1 cellular assay. Compounds containing a trimethoxyphenyl group in the P(1)' substituent demonstrated TACE selectivity across several series of hydroxamate-based inhibitors." @default.
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• W1997614344 date "2001-11-01" @default.
• W1997614344 modified "2023-10-11" @default.
• W1997614344 title "Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-α converting enzyme" @default.
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• W1997614344 doi "https://doi.org/10.1016/s0960-894x(01)00603-5" @default.
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