FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997617266> ?p ?o ?g. }

• W1997617266 endingPage "58" @default.
• W1997617266 startingPage "51" @default.
• W1997617266 abstract "The purpose of this study was to determine whether PTH has anabolic effects on cortical bone in ovariectomized (OVX) rats similar to those previously observed in cancellous bone. Groups of OVX rats were untreated for the first 4 weeks postovariectomy followed by treatment for 5-, 10-, or 15-week periods with vehicle, estrogen, the bisphosphonate risedronate (NE-58095), PTH, PTH + estrogen or PTH + NE-58095. A group of sham-operated control rats was treated with vehicle alone. Cross sections of the tibial diaphysis immediately proximal to the tibiofibular junction were subjected to quantitative bone histomorphometry. In comparison to vehicle-treated control rats, the following structural changes were detected in cortical bone of OVX rats after 15 weeks of vehicle treatment: increased cortical bone tissue area, increased cortical bone area, and a trend for increased bone marrow area. Indices of periosteal bone formation were increased in vehicle-treated OVX rats at 5 weeks, but declined to control levels at the later time points. In addition, vehicle-treated OVX rats exhibited a nonsignificant trend for increased endocortical bone formation relative to vehicle-treated control rats throughout most of the study. Estrogen, but not NE-58095, prevented most of the changes in cortical bone structure associated with ovariectomy. In comparison to vehicle treatment of OVX rats, estrogen decreased both periosteal and endocortical bone formation whereas NE-58095 decreased endocortical, but not periosteal, bone formation. Treatment of OVX rats with PTH alone increased cortical bone area and width as well as decreased bone marrow area compared to vehicle-treated OVX rats. The PTH-induced increase in cortical bone mass was associated with a marked increase in periosteal and endocortical bone formation at 5 weeks of treatment. Afterwards, cortical bone formation in PTH-treated OVX rats declined toward the levels of vehicle-treated control and OVX rats. Concurrent treatment of OVX rats with PTH + estrogen or PTH + NE-58095 blunted somewhat the stimulatory effect of PTH on cortical bone formation, but presumably inhibited endocortical bone resorption as well. As a result, the increase in cortical bone area induced by the concurrent treatments was nearly identical to that of PTH alone. The data indicate that PTH, in contrast to estrogen and NE-58095, stimulates cortical bone formation and augments cortical bone mass in the tibial diaphysis of OVX rats. In this animal model, our findings do not support the contention that PTH augments cancellous bone at the expense of cortical bone in the estrogen-deplete skeleton." @default.
• W1997617266 created "2016-06-24" @default.
• W1997617266 creator A5054610561 @default.
• W1997617266 creator A5088257800 @default.
• W1997617266 date "1994-01-01" @default.
• W1997617266 modified "2023-10-16" @default.
• W1997617266 title "Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats" @default.
• W1997617266 cites W1972828099 @default.
• W1997617266 cites W1975532319 @default.
• W1997617266 cites W1978646400 @default.
• W1997617266 cites W1979471317 @default.
• W1997617266 cites W1996164381 @default.
• W1997617266 cites W2001055663 @default.
• W1997617266 cites W2005843802 @default.
• W1997617266 cites W2015576315 @default.
• W1997617266 cites W2030525320 @default.
• W1997617266 cites W2031148025 @default.
• W1997617266 cites W2036690657 @default.
• W1997617266 cites W2044010302 @default.
• W1997617266 cites W2061593831 @default.
• W1997617266 cites W2064390254 @default.
• W1997617266 cites W2079933145 @default.
• W1997617266 cites W2080885494 @default.
• W1997617266 cites W2088410873 @default.
• W1997617266 cites W2088640839 @default.
• W1997617266 cites W2092629935 @default.
• W1997617266 cites W2092701996 @default.
• W1997617266 cites W2094834328 @default.
• W1997617266 cites W2104134230 @default.
• W1997617266 cites W2116921062 @default.
• W1997617266 cites W2123889083 @default.
• W1997617266 cites W2131914226 @default.
• W1997617266 cites W2132973962 @default.
• W1997617266 cites W2290774861 @default.
• W1997617266 cites W3021709612 @default.
• W1997617266 cites W4232194288 @default.
• W1997617266 cites W4253182120 @default.
• W1997617266 doi "https://doi.org/10.1016/8756-3282(94)90891-5" @default.
• W1997617266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8024852" @default.
• W1997617266 hasPublicationYear "1994" @default.
• W1997617266 type Work @default.
• W1997617266 sameAs 1997617266 @default.
• W1997617266 citedByCount "126" @default.
• W1997617266 countsByYear W19976172662012 @default.
• W1997617266 countsByYear W19976172662013 @default.
• W1997617266 countsByYear W19976172662014 @default.
• W1997617266 countsByYear W19976172662015 @default.
• W1997617266 countsByYear W19976172662016 @default.
• W1997617266 countsByYear W19976172662017 @default.
• W1997617266 countsByYear W19976172662018 @default.
• W1997617266 countsByYear W19976172662021 @default.
• W1997617266 countsByYear W19976172662022 @default.
• W1997617266 crossrefType "journal-article" @default.
• W1997617266 hasAuthorship W1997617266A5054610561 @default.
• W1997617266 hasAuthorship W1997617266A5088257800 @default.
• W1997617266 hasConcept C1008401 @default.
• W1997617266 hasConcept C105702510 @default.
• W1997617266 hasConcept C126322002 @default.
• W1997617266 hasConcept C134018914 @default.
• W1997617266 hasConcept C185592680 @default.
• W1997617266 hasConcept C2776350087 @default.
• W1997617266 hasConcept C2776541429 @default.
• W1997617266 hasConcept C2777164284 @default.
• W1997617266 hasConcept C2781208988 @default.
• W1997617266 hasConcept C2781451080 @default.
• W1997617266 hasConcept C519063684 @default.
• W1997617266 hasConcept C71924100 @default.
• W1997617266 hasConcept C8264082 @default.
• W1997617266 hasConceptScore W1997617266C1008401 @default.
• W1997617266 hasConceptScore W1997617266C105702510 @default.
• W1997617266 hasConceptScore W1997617266C126322002 @default.
• W1997617266 hasConceptScore W1997617266C134018914 @default.
• W1997617266 hasConceptScore W1997617266C185592680 @default.
• W1997617266 hasConceptScore W1997617266C2776350087 @default.
• W1997617266 hasConceptScore W1997617266C2776541429 @default.
• W1997617266 hasConceptScore W1997617266C2777164284 @default.
• W1997617266 hasConceptScore W1997617266C2781208988 @default.
• W1997617266 hasConceptScore W1997617266C2781451080 @default.
• W1997617266 hasConceptScore W1997617266C519063684 @default.
• W1997617266 hasConceptScore W1997617266C71924100 @default.
• W1997617266 hasConceptScore W1997617266C8264082 @default.
• W1997617266 hasIssue "1" @default.
• W1997617266 hasLocation W19976172661 @default.
• W1997617266 hasLocation W19976172662 @default.
• W1997617266 hasOpenAccess W1997617266 @default.
• W1997617266 hasPrimaryLocation W19976172661 @default.
• W1997617266 hasRelatedWork W1977989088 @default.
• W1997617266 hasRelatedWork W2062036890 @default.
• W1997617266 hasRelatedWork W2121755376 @default.
• W1997617266 hasRelatedWork W2374822997 @default.
• W1997617266 hasRelatedWork W2394082980 @default.
• W1997617266 hasRelatedWork W2394384103 @default.
• W1997617266 hasRelatedWork W2939141498 @default.
• W1997617266 hasRelatedWork W3137586205 @default.
• W1997617266 hasRelatedWork W4376618411 @default.
• W1997617266 hasRelatedWork W8755412 @default.
• W1997617266 hasVolume "15" @default.
• W1997617266 isParatext "false" @default.

• next