Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997624194> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1997624194 endingPage "136" @default.
- W1997624194 startingPage "130" @default.
- W1997624194 abstract "CD40 is a member of the TNF receptor super family (tnfrsf) thats role in autoimmunity has been long established. Predominantly studies focus on CD40 as an antigen presenting cell receptor. We and others determined that CD40 acts as a functional receptor on T cells. In fact CD40 is a co-stimulus for T cells potentially precluding the CD28 – B7 costimulation axis. CD40+ T cells (Th40) are highly pathogenic - transferring type 1 diabetes (T1D) to SCID mice. The number and percentage of Th40 cells increases concurrently with insulitits through diabetes onset. An important finding was that blocking CD40 – CD154 interactions prevents T1D onset, and reestablishes homeostatic balance between Th40 cells and traditional, naturally occurring regulatory T cells (Tregs). We discovered a distinct dysregulation between Th40 cells and Tregs during autoimmunity. The actual number and function of Tregs in NOD mice, the model of T1D, is in fact normal. The percentage of Tregs is skewed to appear abnormally low. We determined that Th40 cells over time in NOD mice radically outpace Tregs in number and percentage. Mechanistically Th40 cells have lower levels of the death inducing Fas molecule and are highly resistant to cell death. Th40 cells are capable of producing Th1 cytokines including IFNγ and TNFα but also can produce IL-17A, demonstrating a pro-inflammatory phenotype. Keywords: CD40, TNFR-super family, autoimmunity, Th40, inflammation" @default.
- W1997624194 created "2016-06-24" @default.
- W1997624194 creator A5004534805 @default.
- W1997624194 creator A5057863189 @default.
- W1997624194 creator A5059851485 @default.
- W1997624194 date "2010-05-01" @default.
- W1997624194 modified "2023-09-26" @default.
- W1997624194 title "The Expanding Role of TNF-Receptor Super Family Member CD40 (tnfrsf5) in Autoimmune Disease: Focus on Th40 Cells" @default.
- W1997624194 doi "https://doi.org/10.2174/157339510791111673" @default.
- W1997624194 hasPublicationYear "2010" @default.
- W1997624194 type Work @default.
- W1997624194 sameAs 1997624194 @default.
- W1997624194 citedByCount "20" @default.
- W1997624194 countsByYear W19976241942012 @default.
- W1997624194 countsByYear W19976241942013 @default.
- W1997624194 countsByYear W19976241942014 @default.
- W1997624194 countsByYear W19976241942016 @default.
- W1997624194 countsByYear W19976241942017 @default.
- W1997624194 countsByYear W19976241942019 @default.
- W1997624194 countsByYear W19976241942020 @default.
- W1997624194 countsByYear W19976241942021 @default.
- W1997624194 countsByYear W19976241942022 @default.
- W1997624194 countsByYear W19976241942023 @default.
- W1997624194 crossrefType "journal-article" @default.
- W1997624194 hasAuthorship W1997624194A5004534805 @default.
- W1997624194 hasAuthorship W1997624194A5057863189 @default.
- W1997624194 hasAuthorship W1997624194A5059851485 @default.
- W1997624194 hasConcept C134018914 @default.
- W1997624194 hasConcept C148125776 @default.
- W1997624194 hasConcept C154317977 @default.
- W1997624194 hasConcept C170493617 @default.
- W1997624194 hasConcept C17991360 @default.
- W1997624194 hasConcept C202751555 @default.
- W1997624194 hasConcept C203014093 @default.
- W1997624194 hasConcept C2776090121 @default.
- W1997624194 hasConcept C2776914184 @default.
- W1997624194 hasConcept C2778013207 @default.
- W1997624194 hasConcept C2779234475 @default.
- W1997624194 hasConcept C2780130043 @default.
- W1997624194 hasConcept C39347974 @default.
- W1997624194 hasConcept C54355233 @default.
- W1997624194 hasConcept C555293320 @default.
- W1997624194 hasConcept C55851684 @default.
- W1997624194 hasConcept C86803240 @default.
- W1997624194 hasConcept C8891405 @default.
- W1997624194 hasConcept C95444343 @default.
- W1997624194 hasConceptScore W1997624194C134018914 @default.
- W1997624194 hasConceptScore W1997624194C148125776 @default.
- W1997624194 hasConceptScore W1997624194C154317977 @default.
- W1997624194 hasConceptScore W1997624194C170493617 @default.
- W1997624194 hasConceptScore W1997624194C17991360 @default.
- W1997624194 hasConceptScore W1997624194C202751555 @default.
- W1997624194 hasConceptScore W1997624194C203014093 @default.
- W1997624194 hasConceptScore W1997624194C2776090121 @default.
- W1997624194 hasConceptScore W1997624194C2776914184 @default.
- W1997624194 hasConceptScore W1997624194C2778013207 @default.
- W1997624194 hasConceptScore W1997624194C2779234475 @default.
- W1997624194 hasConceptScore W1997624194C2780130043 @default.
- W1997624194 hasConceptScore W1997624194C39347974 @default.
- W1997624194 hasConceptScore W1997624194C54355233 @default.
- W1997624194 hasConceptScore W1997624194C555293320 @default.
- W1997624194 hasConceptScore W1997624194C55851684 @default.
- W1997624194 hasConceptScore W1997624194C86803240 @default.
- W1997624194 hasConceptScore W1997624194C8891405 @default.
- W1997624194 hasConceptScore W1997624194C95444343 @default.
- W1997624194 hasIssue "2" @default.
- W1997624194 hasLocation W19976241941 @default.
- W1997624194 hasOpenAccess W1997624194 @default.
- W1997624194 hasPrimaryLocation W19976241941 @default.
- W1997624194 hasRelatedWork W1987300863 @default.
- W1997624194 hasRelatedWork W1997624194 @default.
- W1997624194 hasRelatedWork W2005676026 @default.
- W1997624194 hasRelatedWork W2025898635 @default.
- W1997624194 hasRelatedWork W2035478154 @default.
- W1997624194 hasRelatedWork W2123409682 @default.
- W1997624194 hasRelatedWork W2131653078 @default.
- W1997624194 hasRelatedWork W2161153023 @default.
- W1997624194 hasRelatedWork W2169095843 @default.
- W1997624194 hasRelatedWork W2616895908 @default.
- W1997624194 hasVolume "6" @default.
- W1997624194 isParatext "false" @default.
- W1997624194 isRetracted "false" @default.
- W1997624194 magId "1997624194" @default.
- W1997624194 workType "article" @default.