FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997640596> ?p ?o ?g. }

• W1997640596 endingPage "513" @default.
• W1997640596 startingPage "499" @default.
• W1997640596 abstract "NK homeobox genes have been shown to play important roles in cell-type specification and organogenesis. Murine Bapx1, a member of NK homeobox gene family, is expressed in all the cartilageous tissues that undergo endochondral bone formation, and in gut mesentery during embryogenesis, suggesting that Bapx1 may be a key transcription factor ragulating the development of these organs.We generated Bapx1-deficient mice by gene targeting. Bapx1-/- mice exhibited lethal skeletal dysplasia, with abnormal development of the vertebral column and some craniofacial bones, accompanied with asplenia and gastroduodenal malformation. We showed that the proliferative activity of the sclerotome cells, forming the vertebral column, was significantly reduced in Bapx1-/- embryos. The sclerotome cells of the mutants appeared to migrate and condense normally, but subsequent differentiation into the mature vertebral bodies and intervertebral discs were affected. The sclerotome cells in the vertebral bodies failed to differentiate into hypertrophic chondrocytes, as revealed by the undetected expression of Col10a1 and Osteopontin, and the sclerotome cells in the intervertebral discs failed to express the typical extracellular matrix proteins Col2a1, Col9a2 and aggrecan. Furthermore, we investigated the effect of loss of Bapx1 on the expression of some transcription factors, identified to be expressed in the developing sclerotome and be required for normal development of the vertebral column. Among them, we found that the expression of MFH-1 (mesenchyme forkhead-1), which was reported to regulate the proliferation and differentiation of sclerotome cells, was significantly reduced in ventromedial sclerotome cells in Bapx1-/- mice.Our analysis provided evidence that Bapx1 was indispensable for normal development of ventromedial structure of vertebral column and some of craniofacial bones, splenogenesis and morphogenesis of gastroduodenal tract." @default.
• W1997640596 created "2016-06-24" @default.
• W1997640596 creator A5023817300 @default.
• W1997640596 creator A5027791632 @default.
• W1997640596 creator A5028895701 @default.
• W1997640596 creator A5037907117 @default.
• W1997640596 creator A5046954073 @default.
• W1997640596 creator A5053851057 @default.
• W1997640596 date "2000-06-01" @default.
• W1997640596 modified "2023-10-09" @default.
• W1997640596 title "Targeted disruption of the homeobox transcription factor<i>Bapx1</i>results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation" @default.
• W1997640596 cites W1850112872 @default.
• W1997640596 cites W1973738440 @default.
• W1997640596 cites W1981978155 @default.
• W1997640596 cites W2003541586 @default.
• W1997640596 cites W2004537703 @default.
• W1997640596 cites W2007762330 @default.
• W1997640596 cites W2011082242 @default.
• W1997640596 cites W2012626852 @default.
• W1997640596 cites W2015840464 @default.
• W1997640596 cites W2021090151 @default.
• W1997640596 cites W2021258941 @default.
• W1997640596 cites W2023086020 @default.
• W1997640596 cites W2030572098 @default.
• W1997640596 cites W2040686597 @default.
• W1997640596 cites W2040910893 @default.
• W1997640596 cites W2042289885 @default.
• W1997640596 cites W2048994813 @default.
• W1997640596 cites W2053548194 @default.
• W1997640596 cites W2055699737 @default.
• W1997640596 cites W2062822134 @default.
• W1997640596 cites W2063670445 @default.
• W1997640596 cites W2066444776 @default.
• W1997640596 cites W2073500834 @default.
• W1997640596 cites W2073905457 @default.
• W1997640596 cites W2076600697 @default.
• W1997640596 cites W2080361443 @default.
• W1997640596 cites W2080627291 @default.
• W1997640596 cites W2087096075 @default.
• W1997640596 cites W2091080760 @default.
• W1997640596 cites W2097960859 @default.
• W1997640596 cites W2098482903 @default.
• W1997640596 cites W2102720324 @default.
• W1997640596 cites W2109193598 @default.
• W1997640596 cites W2110100419 @default.
• W1997640596 cites W2113198452 @default.
• W1997640596 cites W2127493628 @default.
• W1997640596 cites W2149103345 @default.
• W1997640596 cites W2157544977 @default.
• W1997640596 cites W2163528858 @default.
• W1997640596 cites W2164108959 @default.
• W1997640596 cites W2166913542 @default.
• W1997640596 cites W2557251691 @default.
• W1997640596 doi "https://doi.org/10.1046/j.1365-2443.2000.00339.x" @default.
• W1997640596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10886375" @default.
• W1997640596 hasPublicationYear "2000" @default.
• W1997640596 type Work @default.
• W1997640596 sameAs 1997640596 @default.
• W1997640596 citedByCount "102" @default.
• W1997640596 countsByYear W19976405962012 @default.
• W1997640596 countsByYear W19976405962013 @default.
• W1997640596 countsByYear W19976405962014 @default.
• W1997640596 countsByYear W19976405962015 @default.
• W1997640596 countsByYear W19976405962016 @default.
• W1997640596 countsByYear W19976405962017 @default.
• W1997640596 countsByYear W19976405962018 @default.
• W1997640596 countsByYear W19976405962019 @default.
• W1997640596 countsByYear W19976405962020 @default.
• W1997640596 countsByYear W19976405962021 @default.
• W1997640596 countsByYear W19976405962022 @default.
• W1997640596 countsByYear W19976405962023 @default.
• W1997640596 crossrefType "journal-article" @default.
• W1997640596 hasAuthorship W1997640596A5023817300 @default.
• W1997640596 hasAuthorship W1997640596A5027791632 @default.
• W1997640596 hasAuthorship W1997640596A5028895701 @default.
• W1997640596 hasAuthorship W1997640596A5037907117 @default.
• W1997640596 hasAuthorship W1997640596A5046954073 @default.
• W1997640596 hasAuthorship W1997640596A5053851057 @default.
• W1997640596 hasBestOaLocation W19976405961 @default.
• W1997640596 hasConcept C104317684 @default.
• W1997640596 hasConcept C121587040 @default.
• W1997640596 hasConcept C126322002 @default.
• W1997640596 hasConcept C134018914 @default.
• W1997640596 hasConcept C196843134 @default.
• W1997640596 hasConcept C2776340970 @default.
• W1997640596 hasConcept C54355233 @default.
• W1997640596 hasConcept C71924100 @default.
• W1997640596 hasConcept C86339819 @default.
• W1997640596 hasConcept C86803240 @default.
• W1997640596 hasConcept C95444343 @default.
• W1997640596 hasConceptScore W1997640596C104317684 @default.
• W1997640596 hasConceptScore W1997640596C121587040 @default.
• W1997640596 hasConceptScore W1997640596C126322002 @default.
• W1997640596 hasConceptScore W1997640596C134018914 @default.
• W1997640596 hasConceptScore W1997640596C196843134 @default.
• W1997640596 hasConceptScore W1997640596C2776340970 @default.
• W1997640596 hasConceptScore W1997640596C54355233 @default.
• W1997640596 hasConceptScore W1997640596C71924100 @default.

• next