FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997643195> ?p ?o ?g. }

• W1997643195 endingPage "222" @default.
• W1997643195 startingPage "212" @default.
• W1997643195 abstract "Spermatocytes, the most sensitive male germ cells to heat-induced apoptosis, do not respond to hyperthermia by inducing heat shock proteins (HSPs), including HSP70i, which has been previously shown to confer resistance to apoptosis in somatic cells. To dissect the mechanism of heat-induced apoptosis and to determine if we could protect spermatocytes by expressing HSP70i, we engineered transgenic mice that express in spermatocytes constitutively active heat shock transcription factor (HSF)1. Such HSF1 expression did not lead to transcription of inducible Hsp70 genes, but instead induced caspase-dependent apoptosis that mimicked heat shock-induced death of spermatogenic cells. Both mitochondria-dependent and death receptor-dependent pathways appear to be involved in such HSF1-induced apoptosis: the levels of Bcl-2 family proteins became increased, p53 protein accumulated and expression levels of caspase-8 and death-receptor-interacting proteins (including Fas-associated death domain protein and TNF receptor associated death domain protein) became elevated. Surprisingly, the constitutive spermatocyte-specific expression of HSP70i in double-transgenic males did not protect against such HSF1-induced apoptosis." @default.
• W1997643195 created "2016-06-24" @default.
• W1997643195 creator A5023706702 @default.
• W1997643195 creator A5030655376 @default.
• W1997643195 creator A5050285030 @default.
• W1997643195 creator A5059760088 @default.
• W1997643195 creator A5072616965 @default.
• W1997643195 creator A5073675969 @default.
• W1997643195 creator A5077978023 @default.
• W1997643195 creator A5084891674 @default.
• W1997643195 creator A5088327829 @default.
• W1997643195 date "2005-09-09" @default.
• W1997643195 modified "2023-10-18" @default.
• W1997643195 title "Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells" @default.
• W1997643195 cites W1527817144 @default.
• W1997643195 cites W1564792690 @default.
• W1997643195 cites W1590461098 @default.
• W1997643195 cites W1767355390 @default.
• W1997643195 cites W1876382674 @default.
• W1997643195 cites W1892631247 @default.
• W1997643195 cites W1971495515 @default.
• W1997643195 cites W1972260692 @default.
• W1997643195 cites W1981048926 @default.
• W1997643195 cites W1983735042 @default.
• W1997643195 cites W1989996595 @default.
• W1997643195 cites W1990000982 @default.
• W1997643195 cites W1993064125 @default.
• W1997643195 cites W1996470295 @default.
• W1997643195 cites W2004750062 @default.
• W1997643195 cites W2008712368 @default.
• W1997643195 cites W2010485114 @default.
• W1997643195 cites W2015640955 @default.
• W1997643195 cites W2020357295 @default.
• W1997643195 cites W2022239346 @default.
• W1997643195 cites W2023746083 @default.
• W1997643195 cites W2027704751 @default.
• W1997643195 cites W2040385763 @default.
• W1997643195 cites W2049858779 @default.
• W1997643195 cites W2051793369 @default.
• W1997643195 cites W2057358681 @default.
• W1997643195 cites W2057835131 @default.
• W1997643195 cites W2059901120 @default.
• W1997643195 cites W2065861852 @default.
• W1997643195 cites W2068903746 @default.
• W1997643195 cites W2071518580 @default.
• W1997643195 cites W2074199894 @default.
• W1997643195 cites W2074212982 @default.
• W1997643195 cites W2077506975 @default.
• W1997643195 cites W2081528844 @default.
• W1997643195 cites W2089499612 @default.
• W1997643195 cites W2093518870 @default.
• W1997643195 cites W2102042089 @default.
• W1997643195 cites W2102653482 @default.
• W1997643195 cites W2107528598 @default.
• W1997643195 cites W2108987359 @default.
• W1997643195 cites W2109230097 @default.
• W1997643195 cites W2111877659 @default.
• W1997643195 cites W2115204806 @default.
• W1997643195 cites W2118292263 @default.
• W1997643195 cites W2119624960 @default.
• W1997643195 cites W2120961294 @default.
• W1997643195 cites W2125013026 @default.
• W1997643195 cites W2125093374 @default.
• W1997643195 cites W2127554597 @default.
• W1997643195 cites W2127741693 @default.
• W1997643195 cites W2131778751 @default.
• W1997643195 cites W2153040065 @default.
• W1997643195 cites W2166207515 @default.
• W1997643195 cites W2166442018 @default.
• W1997643195 cites W2174411482 @default.
• W1997643195 cites W2326662261 @default.
• W1997643195 cites W2345413443 @default.
• W1997643195 cites W4230869656 @default.
• W1997643195 cites W4294216491 @default.
• W1997643195 doi "https://doi.org/10.1038/sj.cdd.4401758" @default.
• W1997643195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16151457" @default.
• W1997643195 hasPublicationYear "2005" @default.
• W1997643195 type Work @default.
• W1997643195 sameAs 1997643195 @default.
• W1997643195 citedByCount "49" @default.
• W1997643195 countsByYear W19976431952012 @default.
• W1997643195 countsByYear W19976431952013 @default.
• W1997643195 countsByYear W19976431952014 @default.
• W1997643195 countsByYear W19976431952015 @default.
• W1997643195 countsByYear W19976431952016 @default.
• W1997643195 countsByYear W19976431952017 @default.
• W1997643195 countsByYear W19976431952018 @default.
• W1997643195 countsByYear W19976431952019 @default.
• W1997643195 countsByYear W19976431952020 @default.
• W1997643195 countsByYear W19976431952021 @default.
• W1997643195 crossrefType "journal-article" @default.
• W1997643195 hasAuthorship W1997643195A5023706702 @default.
• W1997643195 hasAuthorship W1997643195A5030655376 @default.
• W1997643195 hasAuthorship W1997643195A5050285030 @default.
• W1997643195 hasAuthorship W1997643195A5059760088 @default.
• W1997643195 hasAuthorship W1997643195A5072616965 @default.
• W1997643195 hasAuthorship W1997643195A5073675969 @default.
• W1997643195 hasAuthorship W1997643195A5077978023 @default.

• next