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• W1997643531 endingPage "1912" @default.
• W1997643531 startingPage "1908" @default.
• W1997643531 abstract "Eukaryotic cells become committed to proliferate during the G1 phase of the cell cycle. In budding yeast, commitment occurs when the catalytic subunit of a protein kinase, encoded by the CDC28 gene (the homolog of the fission yeast cdc2+ gene), binds to a positively acting regulatory subunit, a cyclin. Related kinases are also required for progression through the G1 phase in higher eukaryotes. The role of cyclins in controlling G1 progression in mammalian cells was tested by construction of fibroblasts that constitutively overexpress human cyclin E. This was found to shorten the duration of G1, decrease cell size, and diminish the serum requirement for the transition from G1 to S phase. These observations show that cyclin levels can be rate-limiting for G1 progression in mammalian cells and suggest that cyclin synthesis may be the target of physiological signals that control cell proliferation." @default.
• W1997643531 created "2016-06-24" @default.
• W1997643531 creator A5060192729 @default.
• W1997643531 creator A5084651694 @default.
• W1997643531 date "1993-03-26" @default.
• W1997643531 modified "2023-10-01" @default.
• W1997643531 title "Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts" @default.
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• W1997643531 doi "https://doi.org/10.1126/science.8384376" @default.
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