Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997648398> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1997648398 endingPage "S23" @default.
- W1997648398 startingPage "S23" @default.
- W1997648398 abstract "Chronic myelomonocytic leukemia (CMML) and atypical chronic myeloid leukemia (aCML) are distinct, yet related, entities of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) characterized by morphologic dysplasia with accumulation of monocytes or neutrophils, respectively. Our understanding of the molecular pathogenesis of CMML and aCML has advanced, mainly due to the application of novel technologies such as array-based karyotyping and next-generation sequencing. In addition to previously known recurrent aberrations, somatic uniparental disomy affecting chromosomes 3, 4, 7, and 11 frequently occurs in CMML. Novel somatic mutations of genes, including those associated with proliferation signaling (CBL, RAS, RUNX1, JAK2 (V617F)) and with modification of epigenetic status (TET2, ASXL1, UTX, EZH2) have been found. Various combinations of mutations suggest a multistep pathogenesis and may account for clinical heterogeneity. Most recently, several spliceosome-associated-gene mutations were reported and SRSF2 mutations are frequently detected in CMML. The prognostic and diagnostic significance of these molecular lesions, in particular their value as biomarkers of response or resistance to specific therapies, while uncertain now is likely to be clarified as large systematic studies come to completion." @default.
- W1997648398 created "2016-06-24" @default.
- W1997648398 creator A5002411804 @default.
- W1997648398 creator A5021560939 @default.
- W1997648398 creator A5032550738 @default.
- W1997648398 creator A5039388919 @default.
- W1997648398 creator A5052859085 @default.
- W1997648398 creator A5057501676 @default.
- W1997648398 creator A5065560510 @default.
- W1997648398 creator A5084714374 @default.
- W1997648398 creator A5088167618 @default.
- W1997648398 creator A5088243670 @default.
- W1997648398 creator A5088353355 @default.
- W1997648398 date "2013-05-01" @default.
- W1997648398 modified "2023-10-16" @default.
- W1997648398 title "P-001 Next generation whole exome sequencing for recurrent somatic mutations on chromosome 7" @default.
- W1997648398 doi "https://doi.org/10.1016/s0145-2126(13)70050-x" @default.
- W1997648398 hasPublicationYear "2013" @default.
- W1997648398 type Work @default.
- W1997648398 sameAs 1997648398 @default.
- W1997648398 citedByCount "0" @default.
- W1997648398 crossrefType "journal-article" @default.
- W1997648398 hasAuthorship W1997648398A5002411804 @default.
- W1997648398 hasAuthorship W1997648398A5021560939 @default.
- W1997648398 hasAuthorship W1997648398A5032550738 @default.
- W1997648398 hasAuthorship W1997648398A5039388919 @default.
- W1997648398 hasAuthorship W1997648398A5052859085 @default.
- W1997648398 hasAuthorship W1997648398A5057501676 @default.
- W1997648398 hasAuthorship W1997648398A5065560510 @default.
- W1997648398 hasAuthorship W1997648398A5084714374 @default.
- W1997648398 hasAuthorship W1997648398A5088167618 @default.
- W1997648398 hasAuthorship W1997648398A5088243670 @default.
- W1997648398 hasAuthorship W1997648398A5088353355 @default.
- W1997648398 hasConcept C104317684 @default.
- W1997648398 hasConcept C134305767 @default.
- W1997648398 hasConcept C16671776 @default.
- W1997648398 hasConcept C203014093 @default.
- W1997648398 hasConcept C2777928532 @default.
- W1997648398 hasConcept C2778193527 @default.
- W1997648398 hasConcept C2780007613 @default.
- W1997648398 hasConcept C2780332060 @default.
- W1997648398 hasConcept C2780817109 @default.
- W1997648398 hasConcept C30481170 @default.
- W1997648398 hasConcept C41091548 @default.
- W1997648398 hasConcept C501734568 @default.
- W1997648398 hasConcept C502942594 @default.
- W1997648398 hasConcept C53226629 @default.
- W1997648398 hasConcept C54355233 @default.
- W1997648398 hasConcept C86339819 @default.
- W1997648398 hasConcept C86803240 @default.
- W1997648398 hasConceptScore W1997648398C104317684 @default.
- W1997648398 hasConceptScore W1997648398C134305767 @default.
- W1997648398 hasConceptScore W1997648398C16671776 @default.
- W1997648398 hasConceptScore W1997648398C203014093 @default.
- W1997648398 hasConceptScore W1997648398C2777928532 @default.
- W1997648398 hasConceptScore W1997648398C2778193527 @default.
- W1997648398 hasConceptScore W1997648398C2780007613 @default.
- W1997648398 hasConceptScore W1997648398C2780332060 @default.
- W1997648398 hasConceptScore W1997648398C2780817109 @default.
- W1997648398 hasConceptScore W1997648398C30481170 @default.
- W1997648398 hasConceptScore W1997648398C41091548 @default.
- W1997648398 hasConceptScore W1997648398C501734568 @default.
- W1997648398 hasConceptScore W1997648398C502942594 @default.
- W1997648398 hasConceptScore W1997648398C53226629 @default.
- W1997648398 hasConceptScore W1997648398C54355233 @default.
- W1997648398 hasConceptScore W1997648398C86339819 @default.
- W1997648398 hasConceptScore W1997648398C86803240 @default.
- W1997648398 hasLocation W19976483981 @default.
- W1997648398 hasOpenAccess W1997648398 @default.
- W1997648398 hasPrimaryLocation W19976483981 @default.
- W1997648398 hasRelatedWork W1546418417 @default.
- W1997648398 hasRelatedWork W1556577452 @default.
- W1997648398 hasRelatedWork W2068588654 @default.
- W1997648398 hasRelatedWork W2083005133 @default.
- W1997648398 hasRelatedWork W2123902333 @default.
- W1997648398 hasRelatedWork W2464313322 @default.
- W1997648398 hasRelatedWork W2768522891 @default.
- W1997648398 hasRelatedWork W2979464342 @default.
- W1997648398 hasRelatedWork W4315629143 @default.
- W1997648398 hasRelatedWork W4362666348 @default.
- W1997648398 hasVolume "37" @default.
- W1997648398 isParatext "false" @default.
- W1997648398 isRetracted "false" @default.
- W1997648398 magId "1997648398" @default.
- W1997648398 workType "article" @default.