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• W1997653917 endingPage "509" @default.
• W1997653917 startingPage "499" @default.
• W1997653917 abstract "A single intracheal dose of liposome-encapsuled dichloro-methylene-diphosphonate resulted in the elimination of alveolar macrophages (AM) from the lung, creating a model to study the in vivo role of AM in the pulmonary immune response. Using intratracheally administered trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH), the kinetics of the response, the location and number of TNP-specific antibody-forming cells, and the different Ig classes of the antibodies produced were studied in AM-depleted animals. The results show that AM elimination has a dramatic effect on the pulmonary immune responses against TNP-KLH. An increase in APC in lung-associated lymph nodes and a prolongation of the response is found, as well as an introduction of APC in lung tissue. In both experimental groups, the majority of the TNP-specific antibodies produced was IgG, followed by IgA and IgE, while very few IgM antibodies could be detected. We conclude from these results that AM are likely to play a role in controlling the pulmonary immune response in a suppressive way, thereby limiting the possible damage caused by severe immune responses in lung tissue." @default.
• W1997653917 created "2016-06-24" @default.
• W1997653917 creator A5061627362 @default.
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• W1997653917 date "1989-08-01" @default.
• W1997653917 modified "2023-10-16" @default.
• W1997653917 title "Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice." @default.
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• W1997653917 doi "https://doi.org/10.1084/jem.170.2.499" @default.
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