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- W1997656140 abstract "Human induced pluripotent stem cells (hiPSCs) hold enormous potential, however several obstacles impede their translation to industrial and clinical applications. Here we describe a platform to efficiently generate, characterize and maintain single cell and feeder-free (FF) cultured hiPSCs by means of a small molecule cocktail media additive. Using this strategy we have developed an effective multiplex sorting and high-throughput selection platform where individual clonal hiPSC lines are readily obtained from a pool of candidate clones, expanded and thoroughly characterized. By promoting survival and self-renewal, the selected hiPSC clones can be rapidly expanded over multiple FF, single-cell passages while maintaining their pluripotency and genomic stability as demonstrated by trilineage differentiation, karyotype and copy number variation analysis. This study provides a robust platform that increases efficiency, throughput, scale and quality of hiPSC generation and facilitates the industrial and clinical use of iPSC technology." @default.
- W1997656140 created "2016-06-24" @default.
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- W1997656140 date "2012-01-06" @default.
- W1997656140 modified "2023-10-06" @default.
- W1997656140 title "A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs" @default.
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- W1997656140 doi "https://doi.org/10.1038/srep00213" @default.
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