Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997659581> ?p ?o ?g. }
- W1997659581 endingPage "92" @default.
- W1997659581 startingPage "84" @default.
- W1997659581 abstract "The combination of chemotherapy with photothermal therapy, which may lead to improved therapeutic efficacies and reduced side effects of conventional chemotherapy, would require safe drug delivery systems (DDSs) with strong near-infrared (NIR) absorbance, efficient drug loading, and effective tumor homing ability. Herein, we fabricate nano-assemblies containing J-aggregates of a NIR dye, IR825, for drug delivery and combined photothermal & chemotherapy of cancer. It is found that IR825 could be complexed with a low-molecular-weight cationic polymer polyethylenimine (PEI), forming IR825@PEI J-aggregates with greatly enhanced NIR absorbance red-shifted to 915 nm. Those nano-assemblies of J-aggregates are further modified with polyethylene glycol (PEG), obtaining IR825@PEI-PEG nano-complex which exhibits great dispersity in physiological solutions, excellent photostability, and is able to efficiently load chemotherapeutic drug doxorubicin (DOX) via a unique strategy different from drug loading in conventional amphiphilic polymer-based DDSs. In vivo animal experiments uncover that IR825@PEI-PEG/DOX upon intravenous injection into tumor-bearing mice shows rather high tumor uptake as illustrated by photoacoustic imaging. In vivo combined photothermal & chemotherapy is then carried out, demonstrating great synergistic anti-tumor therapeutic effect remarkably superior to those achieved by the respective mono-therapies. Hence, we present a novel type of nanoscale DDSs based on nano-assemblies of small molecules without involving amphiphilic polymers, promising for imaging-guided combination cancer therapy." @default.
- W1997659581 created "2016-06-24" @default.
- W1997659581 creator A5038895849 @default.
- W1997659581 creator A5061592658 @default.
- W1997659581 creator A5065037360 @default.
- W1997659581 creator A5068290128 @default.
- W1997659581 creator A5084000653 @default.
- W1997659581 creator A5084452813 @default.
- W1997659581 date "2015-07-01" @default.
- W1997659581 modified "2023-10-11" @default.
- W1997659581 title "Nano-assemblies of J-aggregates based on a NIR dye as a multifunctional drug carrier for combination cancer therapy" @default.
- W1997659581 cites W1921100808 @default.
- W1997659581 cites W1963979857 @default.
- W1997659581 cites W1968927007 @default.
- W1997659581 cites W1975600099 @default.
- W1997659581 cites W1977858111 @default.
- W1997659581 cites W1988356468 @default.
- W1997659581 cites W2002062311 @default.
- W1997659581 cites W2002500131 @default.
- W1997659581 cites W2005299431 @default.
- W1997659581 cites W2009598580 @default.
- W1997659581 cites W2009749128 @default.
- W1997659581 cites W2010790814 @default.
- W1997659581 cites W2016081404 @default.
- W1997659581 cites W2024714448 @default.
- W1997659581 cites W2026972453 @default.
- W1997659581 cites W2027929569 @default.
- W1997659581 cites W2032760352 @default.
- W1997659581 cites W2038324672 @default.
- W1997659581 cites W2038977078 @default.
- W1997659581 cites W2039171477 @default.
- W1997659581 cites W2047207319 @default.
- W1997659581 cites W2047358259 @default.
- W1997659581 cites W2048363327 @default.
- W1997659581 cites W2063759313 @default.
- W1997659581 cites W2082352755 @default.
- W1997659581 cites W2100382811 @default.
- W1997659581 cites W2101673712 @default.
- W1997659581 cites W2102449174 @default.
- W1997659581 cites W2106903199 @default.
- W1997659581 cites W2112381014 @default.
- W1997659581 cites W2120377744 @default.
- W1997659581 cites W2121892940 @default.
- W1997659581 cites W2123168883 @default.
- W1997659581 cites W2129166766 @default.
- W1997659581 cites W2133764807 @default.
- W1997659581 cites W2149881777 @default.
- W1997659581 cites W2154338418 @default.
- W1997659581 cites W2156124327 @default.
- W1997659581 cites W2161105252 @default.
- W1997659581 cites W2175000645 @default.
- W1997659581 cites W2316291164 @default.
- W1997659581 cites W2320589001 @default.
- W1997659581 cites W2322194440 @default.
- W1997659581 cites W2329353330 @default.
- W1997659581 cites W4232371418 @default.
- W1997659581 cites W4235498483 @default.
- W1997659581 doi "https://doi.org/10.1016/j.biomaterials.2015.04.001" @default.
- W1997659581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25913253" @default.
- W1997659581 hasPublicationYear "2015" @default.
- W1997659581 type Work @default.
- W1997659581 sameAs 1997659581 @default.
- W1997659581 citedByCount "91" @default.
- W1997659581 countsByYear W19976595812015 @default.
- W1997659581 countsByYear W19976595812016 @default.
- W1997659581 countsByYear W19976595812017 @default.
- W1997659581 countsByYear W19976595812018 @default.
- W1997659581 countsByYear W19976595812019 @default.
- W1997659581 countsByYear W19976595812020 @default.
- W1997659581 countsByYear W19976595812021 @default.
- W1997659581 countsByYear W19976595812022 @default.
- W1997659581 countsByYear W19976595812023 @default.
- W1997659581 crossrefType "journal-article" @default.
- W1997659581 hasAuthorship W1997659581A5038895849 @default.
- W1997659581 hasAuthorship W1997659581A5061592658 @default.
- W1997659581 hasAuthorship W1997659581A5065037360 @default.
- W1997659581 hasAuthorship W1997659581A5068290128 @default.
- W1997659581 hasAuthorship W1997659581A5084000653 @default.
- W1997659581 hasAuthorship W1997659581A5084452813 @default.
- W1997659581 hasConcept C10138342 @default.
- W1997659581 hasConcept C104317684 @default.
- W1997659581 hasConcept C141071460 @default.
- W1997659581 hasConcept C15083742 @default.
- W1997659581 hasConcept C150903083 @default.
- W1997659581 hasConcept C155672457 @default.
- W1997659581 hasConcept C15920480 @default.
- W1997659581 hasConcept C159985019 @default.
- W1997659581 hasConcept C162324750 @default.
- W1997659581 hasConcept C171250308 @default.
- W1997659581 hasConcept C178790620 @default.
- W1997659581 hasConcept C182606246 @default.
- W1997659581 hasConcept C185592680 @default.
- W1997659581 hasConcept C192562407 @default.
- W1997659581 hasConcept C207001950 @default.
- W1997659581 hasConcept C2775925850 @default.
- W1997659581 hasConcept C2776694085 @default.
- W1997659581 hasConcept C2776964284 @default.
- W1997659581 hasConcept C2779149719 @default.