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• W1997676005 abstract "A clearance method based on the analysis of a disappearance curve of suitable substances from the plasma was used for the purpose of determining the renal function of 99 children, ranging in age from 6 months to 17 years, with known or suspected renal disease. The disappearance of 125I-sodium iothalamate and 131I-orthoiodohippurate after a single injection was tested in 75 children, and was found to yield results which correlated closely with the clearance obtained by continuous infusion of inulin (Y=0.93X+14.5, r=+0.87) and p-aminohippuric acid (Y=0.80X+38.6, r=+0.93), respectively. The radiation dose for the combined procedure was estimated to be less than 0.133 millirad per microcurie to the whole body and 0.25 millirad per microcurie to the kidneys. The plasma disappearance curve following an injection of “cold” inulin was also found to provide an accurate estimate of the glomerular filtration rate, when compared with the clearance of endogenous creatinine (Y=1.07X+0.3, r=+0.89). The single injection method, with the important advantage of obviating the need for urine collection, appears to offer a reliable alternative to the standard clearance technique when appropriate regression equations are applied. The choice between the use of radioactive substances and inulin should be based on consideration of factors such as the need for repeat testing, availability of isotope-counting equipment, and accessibility of reliable chemical determinations. A clearance method based on the analysis of a disappearance curve of suitable substances from the plasma was used for the purpose of determining the renal function of 99 children, ranging in age from 6 months to 17 years, with known or suspected renal disease. The disappearance of 125I-sodium iothalamate and 131I-orthoiodohippurate after a single injection was tested in 75 children, and was found to yield results which correlated closely with the clearance obtained by continuous infusion of inulin (Y=0.93X+14.5, r=+0.87) and p-aminohippuric acid (Y=0.80X+38.6, r=+0.93), respectively. The radiation dose for the combined procedure was estimated to be less than 0.133 millirad per microcurie to the whole body and 0.25 millirad per microcurie to the kidneys. The plasma disappearance curve following an injection of “cold” inulin was also found to provide an accurate estimate of the glomerular filtration rate, when compared with the clearance of endogenous creatinine (Y=1.07X+0.3, r=+0.89). The single injection method, with the important advantage of obviating the need for urine collection, appears to offer a reliable alternative to the standard clearance technique when appropriate regression equations are applied. The choice between the use of radioactive substances and inulin should be based on consideration of factors such as the need for repeat testing, availability of isotope-counting equipment, and accessibility of reliable chemical determinations." @default.
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• W1997676005 date "1973-11-01" @default.
• W1997676005 modified "2023-10-01" @default.
• W1997676005 title "Simultaneous measurement of glomerular filtration rate and renal plasma flow using plasma disappearance curves" @default.
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• W1997676005 doi "https://doi.org/10.1016/s0022-3476(73)80365-8" @default.
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