Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997680500> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1997680500 endingPage "698" @default.
- W1997680500 startingPage "694" @default.
- W1997680500 abstract "The classic form of Ehlers-Danlos syndrome (cEDS) is an inherited connective tissue disorder, where mutations in type V collagen-encoding genes result in abnormal collagen fibrils. Thus the cEDS patients have pathological connective tissue morphology and low stiffness, but the rate of connective tissue protein turnover is unknown. We investigated whether cEDS affected the protein synthesis rate in skin and tendon, and whether this could be stimulated in tendon tissue with insulin-like growth factor-I (IGF-I). Five patients with cEDS and 10 healthy, matched controls (CTRL) were included. One patellar tendon of each participant was injected with 0.1 ml IGF-I (Increlex, Ipsen, 10 mg/ml) and the contralateral tendon with 0.1 ml isotonic saline as control. The injections were performed at both 24 and 6 h prior to tissue sampling. The fractional synthesis rate (FSR) of proteins in skin and tendon was measured with the stable isotope technique using a flood-primed continuous infusion over 6 h. After the infusion one skin biopsy and two tendon biopsies (one from each patellar tendon) were obtained. We found similar baseline FSR values in skin and tendon in the cEDS patients and controls [skin: 0.005 ± 0.002 (cEDS) and 0.007 ± 0.002 (CTRL); tendon: 0.008 ± 0.001 (cEDS) and 0.009 ± 0.002 (CTRL) %/h, mean ± SE]. IGF-I injections significantly increased FSR values in cEDS patients but not in controls (delta values: cEDS 0.007 ± 0.002, CTRL 0.001 ± 0.001%/h). In conclusion, baseline protein synthesis rates in connective tissue appeared normal in cEDS patients, and the patients responded with an increased tendon protein synthesis rate to IGF-I injections." @default.
- W1997680500 created "2016-06-24" @default.
- W1997680500 creator A5020947950 @default.
- W1997680500 creator A5021464315 @default.
- W1997680500 creator A5044237109 @default.
- W1997680500 creator A5044407583 @default.
- W1997680500 creator A5052508918 @default.
- W1997680500 creator A5071353414 @default.
- W1997680500 date "2014-10-01" @default.
- W1997680500 modified "2023-10-02" @default.
- W1997680500 title "Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I" @default.
- W1997680500 cites W1578717458 @default.
- W1997680500 cites W1917942675 @default.
- W1997680500 cites W1972134844 @default.
- W1997680500 cites W1989107008 @default.
- W1997680500 cites W2000808518 @default.
- W1997680500 cites W2012792811 @default.
- W1997680500 cites W2030578048 @default.
- W1997680500 cites W2032667301 @default.
- W1997680500 cites W2041857716 @default.
- W1997680500 cites W2047351375 @default.
- W1997680500 cites W2050234611 @default.
- W1997680500 cites W2053117318 @default.
- W1997680500 cites W2069356098 @default.
- W1997680500 cites W2069964444 @default.
- W1997680500 cites W2092877017 @default.
- W1997680500 cites W2106051489 @default.
- W1997680500 cites W2112060726 @default.
- W1997680500 cites W2138547056 @default.
- W1997680500 cites W2152518735 @default.
- W1997680500 cites W2153707891 @default.
- W1997680500 cites W2167028176 @default.
- W1997680500 doi "https://doi.org/10.1152/japplphysiol.00157.2014" @default.
- W1997680500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25103963" @default.
- W1997680500 hasPublicationYear "2014" @default.
- W1997680500 type Work @default.
- W1997680500 sameAs 1997680500 @default.
- W1997680500 citedByCount "11" @default.
- W1997680500 countsByYear W19976805002015 @default.
- W1997680500 countsByYear W19976805002016 @default.
- W1997680500 countsByYear W19976805002017 @default.
- W1997680500 countsByYear W19976805002019 @default.
- W1997680500 countsByYear W19976805002021 @default.
- W1997680500 countsByYear W19976805002022 @default.
- W1997680500 countsByYear W19976805002023 @default.
- W1997680500 crossrefType "journal-article" @default.
- W1997680500 hasAuthorship W1997680500A5020947950 @default.
- W1997680500 hasAuthorship W1997680500A5021464315 @default.
- W1997680500 hasAuthorship W1997680500A5044237109 @default.
- W1997680500 hasAuthorship W1997680500A5044407583 @default.
- W1997680500 hasAuthorship W1997680500A5052508918 @default.
- W1997680500 hasAuthorship W1997680500A5071353414 @default.
- W1997680500 hasConcept C126322002 @default.
- W1997680500 hasConcept C134018914 @default.
- W1997680500 hasConcept C141071460 @default.
- W1997680500 hasConcept C142724271 @default.
- W1997680500 hasConcept C170493617 @default.
- W1997680500 hasConcept C2775960820 @default.
- W1997680500 hasConcept C2780105995 @default.
- W1997680500 hasConcept C2780689927 @default.
- W1997680500 hasConcept C518705261 @default.
- W1997680500 hasConcept C71924100 @default.
- W1997680500 hasConceptScore W1997680500C126322002 @default.
- W1997680500 hasConceptScore W1997680500C134018914 @default.
- W1997680500 hasConceptScore W1997680500C141071460 @default.
- W1997680500 hasConceptScore W1997680500C142724271 @default.
- W1997680500 hasConceptScore W1997680500C170493617 @default.
- W1997680500 hasConceptScore W1997680500C2775960820 @default.
- W1997680500 hasConceptScore W1997680500C2780105995 @default.
- W1997680500 hasConceptScore W1997680500C2780689927 @default.
- W1997680500 hasConceptScore W1997680500C518705261 @default.
- W1997680500 hasConceptScore W1997680500C71924100 @default.
- W1997680500 hasIssue "7" @default.
- W1997680500 hasLocation W19976805001 @default.
- W1997680500 hasLocation W19976805002 @default.
- W1997680500 hasOpenAccess W1997680500 @default.
- W1997680500 hasPrimaryLocation W19976805001 @default.
- W1997680500 hasRelatedWork W2000727265 @default.
- W1997680500 hasRelatedWork W2038000824 @default.
- W1997680500 hasRelatedWork W2087090518 @default.
- W1997680500 hasRelatedWork W2098742882 @default.
- W1997680500 hasRelatedWork W2099882033 @default.
- W1997680500 hasRelatedWork W2103096725 @default.
- W1997680500 hasRelatedWork W2130332764 @default.
- W1997680500 hasRelatedWork W2137349730 @default.
- W1997680500 hasRelatedWork W4236502113 @default.
- W1997680500 hasRelatedWork W4253507841 @default.
- W1997680500 hasVolume "117" @default.
- W1997680500 isParatext "false" @default.
- W1997680500 isRetracted "false" @default.
- W1997680500 magId "1997680500" @default.
- W1997680500 workType "article" @default.