Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997690734> ?p ?o ?g. }
- W1997690734 endingPage "1281" @default.
- W1997690734 startingPage "1270" @default.
- W1997690734 abstract "Scope The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level. Methods and results Apo E –/– mice were fed with curcumin at 0.2% (wt/wt) in diet for 4 months. This supplementation reduced the extent of atherosclerotic lesion by 26% and induced changes in expression of genes implicated in cell adhesion and transendothelial migration or cytoskeleton organization, as revealed by a transcriptomic analysis in the aorta. Expression profile of these genes suggests reduction in both leukocyte adhesion and transendothelial migration. In agreement with this hypothesis, we observed a reduction (–37%) in macrophage infiltration in the plaque, as measured by immunohistochemistry, and, in vitro, a lower adhesion of monocytes to TNF ‐α‐stimulated endothelial cells (–32%) after exposure to a nutritionally achievable concentration of curcumin. These changes in gene expression could be related to the observed increased expression of I κ B protein and decrease of TNF ‐α‐induced NF ‐κ B / DNA binding and NF ‐κ B ‐transcriptional activity upon exposure to curcumin. Conclusion Our findings pointed out that the antiatherogenic effect of curcumin could be linked to its effect on gene networks and cell functions related to leukocyte adhesion and transendothelial migration via NF ‐κ B ‐dependent pathways." @default.
- W1997690734 created "2016-06-24" @default.
- W1997690734 creator A5002658464 @default.
- W1997690734 creator A5019729646 @default.
- W1997690734 creator A5026250470 @default.
- W1997690734 creator A5051392431 @default.
- W1997690734 creator A5052226197 @default.
- W1997690734 creator A5059336112 @default.
- W1997690734 creator A5079937001 @default.
- W1997690734 creator A5086716019 @default.
- W1997690734 creator A5088944571 @default.
- W1997690734 date "2012-07-02" @default.
- W1997690734 modified "2023-10-18" @default.
- W1997690734 title "Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration" @default.
- W1997690734 cites W1506756493 @default.
- W1997690734 cites W1914622032 @default.
- W1997690734 cites W1972230443 @default.
- W1997690734 cites W1976630082 @default.
- W1997690734 cites W1977109672 @default.
- W1997690734 cites W1980828424 @default.
- W1997690734 cites W1983606163 @default.
- W1997690734 cites W1990052798 @default.
- W1997690734 cites W1990156172 @default.
- W1997690734 cites W1992465162 @default.
- W1997690734 cites W1993646281 @default.
- W1997690734 cites W2000152750 @default.
- W1997690734 cites W2001798594 @default.
- W1997690734 cites W2001903821 @default.
- W1997690734 cites W2007086019 @default.
- W1997690734 cites W2009748840 @default.
- W1997690734 cites W2019222155 @default.
- W1997690734 cites W2033431239 @default.
- W1997690734 cites W2033685145 @default.
- W1997690734 cites W2035817205 @default.
- W1997690734 cites W2037222034 @default.
- W1997690734 cites W2041996163 @default.
- W1997690734 cites W2051887465 @default.
- W1997690734 cites W2052187514 @default.
- W1997690734 cites W2054805566 @default.
- W1997690734 cites W2058538833 @default.
- W1997690734 cites W2062285651 @default.
- W1997690734 cites W2064338048 @default.
- W1997690734 cites W2069981372 @default.
- W1997690734 cites W2076826671 @default.
- W1997690734 cites W2088167784 @default.
- W1997690734 cites W2096685256 @default.
- W1997690734 cites W2102992354 @default.
- W1997690734 cites W2111114352 @default.
- W1997690734 cites W2118447955 @default.
- W1997690734 cites W2118837782 @default.
- W1997690734 cites W2119033402 @default.
- W1997690734 cites W2120873276 @default.
- W1997690734 cites W2129397604 @default.
- W1997690734 cites W2129884254 @default.
- W1997690734 cites W2134433534 @default.
- W1997690734 cites W2134667046 @default.
- W1997690734 cites W2136160261 @default.
- W1997690734 cites W2138508372 @default.
- W1997690734 cites W2140811295 @default.
- W1997690734 cites W2141554996 @default.
- W1997690734 cites W2150089458 @default.
- W1997690734 cites W2150491978 @default.
- W1997690734 cites W2150579866 @default.
- W1997690734 cites W2151101177 @default.
- W1997690734 cites W2155671521 @default.
- W1997690734 cites W2166977775 @default.
- W1997690734 cites W2170079782 @default.
- W1997690734 cites W2205051901 @default.
- W1997690734 cites W2238003553 @default.
- W1997690734 cites W2324841714 @default.
- W1997690734 cites W2419269917 @default.
- W1997690734 cites W4256475235 @default.
- W1997690734 doi "https://doi.org/10.1002/mnfr.201100818" @default.
- W1997690734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22753158" @default.
- W1997690734 hasPublicationYear "2012" @default.
- W1997690734 type Work @default.
- W1997690734 sameAs 1997690734 @default.
- W1997690734 citedByCount "79" @default.
- W1997690734 countsByYear W19976907342012 @default.
- W1997690734 countsByYear W19976907342013 @default.
- W1997690734 countsByYear W19976907342014 @default.
- W1997690734 countsByYear W19976907342015 @default.
- W1997690734 countsByYear W19976907342016 @default.
- W1997690734 countsByYear W19976907342017 @default.
- W1997690734 countsByYear W19976907342018 @default.
- W1997690734 countsByYear W19976907342019 @default.
- W1997690734 countsByYear W19976907342020 @default.
- W1997690734 countsByYear W19976907342021 @default.
- W1997690734 countsByYear W19976907342022 @default.
- W1997690734 countsByYear W19976907342023 @default.
- W1997690734 crossrefType "journal-article" @default.
- W1997690734 hasAuthorship W1997690734A5002658464 @default.
- W1997690734 hasAuthorship W1997690734A5019729646 @default.
- W1997690734 hasAuthorship W1997690734A5026250470 @default.
- W1997690734 hasAuthorship W1997690734A5051392431 @default.
- W1997690734 hasAuthorship W1997690734A5052226197 @default.
- W1997690734 hasAuthorship W1997690734A5059336112 @default.
- W1997690734 hasAuthorship W1997690734A5079937001 @default.