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• W1997702964 endingPage "198" @default.
• W1997702964 startingPage "87" @default.
• W1997702964 abstract "Abstract All drugs act on discrete pharmacological receptors; however, their clinical use relies on their pharmacodisposition and pharmacokinetics combining to give an appropriate pharmacological response, coupled with the ability of the body to detoxify itself of any drug that has generally distributed. Although to date it has usually been possible to achieve drugs having these properties, not only are the disease targets becoming more difficult to attain, but the probabilities for success using the various high throughput screening techniques often employed are becoming low. The advent of the control of gene expression has given rise to both a plethora of new molecules and an understanding of normal and pathological processes; this is leading to new approaches to both the design and the clinical use of drugs. For these new classes of drugs, and for many drugs of the conventional type, there is a firm rationale for their site-specific delivery using carrier technology — such that the innate biological pathway of the carrier guide the drug to its pharmacological receptor in a protective form. This present contribution examines the rationale for site-specific drug delivery in terms of disease and drug and carrier properties, and the biological constraints and opportunities for site-specific drug delivery are examined by considering carrier access, retention and ability to control the timing of drug availability at site(s) of action(s). Although site-specific drug delivery is still rather empirical in its practice, examples are drawn from the literature to show the mistakes and successes in the use of site-specific carriers. These include their employment in macrophage activation, some other forms of cancer chemotherapy, retroviral diseases (including AIDS/ARC), gene therapy, enzyme-storage diseases, inflammation, graft versus host rejection disease, and fungal infestations. In addition, the challenges presented for the successful pharmaceutical development and clinical use of both soluble macromolecular and particulate colloidal carrier systems are discussed." @default.
• W1997702964 created "2016-06-24" @default.
• W1997702964 creator A5061358140 @default.
• W1997702964 date "1987-12-01" @default.
• W1997702964 modified "2023-09-23" @default.
• W1997702964 title "Theory and practice of site-specific drug delivery" @default.
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