Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997709509> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1997709509 abstract "Store operated calcium channels (SOCs) play a central role in regulating calcium concentrations in non-excitable cells and are critical for many physiological processes including activation of the immune system. SOCs in lymphocytes are mediated by the ion channel Orai that is activated by the endoplasmic reticulum protein STIM through direct binding. Pharmacological blockers of Orai and STIM would be useful tools for basic research in addition to providing potential treatments for autoimmune disorders. We have developed a novel methodology for generating SOC blockers based on identification and targeting the functional domains of STIM and Orai. We have identified a peptide blocker of Orai that is a potent and specific inhibitor of the channel and a small molecule blocker that can inhibit the channel at low micromolar concentrations. We have shown that the small molecule blocker can inhibit T cell activation both in vitro and in vivo. These studies provide an important set of tools for studying STIM and Orai and lead compounds that could be developed into clinically useful agents." @default.
- W1997709509 created "2016-06-24" @default.
- W1997709509 creator A5004406457 @default.
- W1997709509 creator A5026666019 @default.
- W1997709509 creator A5044107758 @default.
- W1997709509 date "2012-01-01" @default.
- W1997709509 modified "2023-09-26" @default.
- W1997709509 title "Identification and Evaluation of Inhibitors of Orai Channels using a Novel Methodology" @default.
- W1997709509 doi "https://doi.org/10.1016/j.bpj.2011.11.3758" @default.
- W1997709509 hasPublicationYear "2012" @default.
- W1997709509 type Work @default.
- W1997709509 sameAs 1997709509 @default.
- W1997709509 citedByCount "0" @default.
- W1997709509 crossrefType "journal-article" @default.
- W1997709509 hasAuthorship W1997709509A5004406457 @default.
- W1997709509 hasAuthorship W1997709509A5026666019 @default.
- W1997709509 hasAuthorship W1997709509A5044107758 @default.
- W1997709509 hasBestOaLocation W19977095091 @default.
- W1997709509 hasConcept C150903083 @default.
- W1997709509 hasConcept C158617107 @default.
- W1997709509 hasConcept C161624437 @default.
- W1997709509 hasConcept C162740809 @default.
- W1997709509 hasConcept C178790620 @default.
- W1997709509 hasConcept C185592680 @default.
- W1997709509 hasConcept C202751555 @default.
- W1997709509 hasConcept C207001950 @default.
- W1997709509 hasConcept C519063684 @default.
- W1997709509 hasConcept C55493867 @default.
- W1997709509 hasConcept C70721500 @default.
- W1997709509 hasConcept C85520022 @default.
- W1997709509 hasConcept C86803240 @default.
- W1997709509 hasConcept C98274493 @default.
- W1997709509 hasConceptScore W1997709509C150903083 @default.
- W1997709509 hasConceptScore W1997709509C158617107 @default.
- W1997709509 hasConceptScore W1997709509C161624437 @default.
- W1997709509 hasConceptScore W1997709509C162740809 @default.
- W1997709509 hasConceptScore W1997709509C178790620 @default.
- W1997709509 hasConceptScore W1997709509C185592680 @default.
- W1997709509 hasConceptScore W1997709509C202751555 @default.
- W1997709509 hasConceptScore W1997709509C207001950 @default.
- W1997709509 hasConceptScore W1997709509C519063684 @default.
- W1997709509 hasConceptScore W1997709509C55493867 @default.
- W1997709509 hasConceptScore W1997709509C70721500 @default.
- W1997709509 hasConceptScore W1997709509C85520022 @default.
- W1997709509 hasConceptScore W1997709509C86803240 @default.
- W1997709509 hasConceptScore W1997709509C98274493 @default.
- W1997709509 hasLocation W19977095091 @default.
- W1997709509 hasOpenAccess W1997709509 @default.
- W1997709509 hasPrimaryLocation W19977095091 @default.
- W1997709509 hasRelatedWork W1571311328 @default.
- W1997709509 hasRelatedWork W1976003350 @default.
- W1997709509 hasRelatedWork W2003189203 @default.
- W1997709509 hasRelatedWork W2022403987 @default.
- W1997709509 hasRelatedWork W2029205555 @default.
- W1997709509 hasRelatedWork W2045505533 @default.
- W1997709509 hasRelatedWork W2090902111 @default.
- W1997709509 hasRelatedWork W2110226839 @default.
- W1997709509 hasRelatedWork W2157254536 @default.
- W1997709509 hasRelatedWork W2254349165 @default.
- W1997709509 hasRelatedWork W2272590574 @default.
- W1997709509 hasRelatedWork W2345685532 @default.
- W1997709509 hasRelatedWork W2385460697 @default.
- W1997709509 hasRelatedWork W2469523769 @default.
- W1997709509 hasRelatedWork W2884136317 @default.
- W1997709509 hasRelatedWork W2903878662 @default.
- W1997709509 hasRelatedWork W2921398125 @default.
- W1997709509 hasRelatedWork W2975135456 @default.
- W1997709509 hasRelatedWork W3042716726 @default.
- W1997709509 hasRelatedWork W2521883502 @default.
- W1997709509 isParatext "false" @default.
- W1997709509 isRetracted "false" @default.
- W1997709509 magId "1997709509" @default.
- W1997709509 workType "article" @default.