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- W1997713382 abstract "The successive emergence of highly pathogenic coronaviruses (CoVs) such as the Severe Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012 has stimulated a number of studies on the molecular biology. This research has provided significant new insight into functions and activities of the replication/transcription multi-protein complex. The latter directs both continuous and discontinuous RNA synthesis to replicate and transcribe the large coronavirus genome made of a single-stranded, positive-sense RNA of ∼30 kb. In this review, we summarize our current understanding of SARS-CoV enzymes involved in RNA biochemistry, such as the in vitro characterization of a highly active and processive RNA polymerase complex which can associate with methyltransferase and 3′–5′ exoribonuclease activities involved in RNA capping, and RNA proofreading, respectively. The recent discoveries reveal fascinating RNA-synthesizing machinery, highlighting the unique position of coronaviruses in the RNA virus world." @default.
- W1997713382 created "2016-06-24" @default.
- W1997713382 creator A5039783946 @default.
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- W1997713382 creator A5067074504 @default.
- W1997713382 creator A5068775377 @default.
- W1997713382 creator A5088791956 @default.
- W1997713382 date "2014-12-01" @default.
- W1997713382 modified "2023-09-29" @default.
- W1997713382 title "Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus" @default.
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- W1997713382 doi "https://doi.org/10.1016/j.virusres.2014.10.008" @default.
- W1997713382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7114481" @default.