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• W1997715561 abstract "In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (1997-2001; n = 1,381; mean age = 59 years; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p < 0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p < 0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p < 0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation." @default.
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• W1997715561 date "2007-11-27" @default.
• W1997715561 modified "2023-10-11" @default.
• W1997715561 title "Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study" @default.
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• W1997715561 doi "https://doi.org/10.1093/aje/kwm306" @default.
• W1997715561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3151653" @default.
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