FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997716013> ?p ?o ?g. }

• W1997716013 endingPage "100" @default.
• W1997716013 startingPage "77" @default.
• W1997716013 abstract "Afferents to the median-paramedian raphe nuclear complex, which contains the B8 serotonergic cell group, were investigated in the rat with neuroanatomical and transmitter-selective retrograde labelling techniques. Injection of sensitive retrograde tracers, cholera toxin genoid or wheat germ agglutinin conjugated horseradish peroxidase into the median raphe resulted in labelling of neurons in a large number of brain regions. Projections from 26 of these regions are supported by available orthograde tracing data; the cingulate cortex, bed nucleus of stria terminalis, medial septum and diagonal band of Broca, ventral pallidum, medial and lateral preoptic areas, lateral hypothalamus, dorsomedial nucleus of hypothalamus, lateral habenula, interpeduncular nucleus, substantia nigra, central (periaqueductal) gray, and laterodorsal tegmental nucleus seem to represent major sources of afferents to the median-paramedian raphe complex. Retrogradely labelled cells were also observed in a number of regions for which anterograde tracing data are not available, including the perifornical hypothalamic nucleus, ventral premammillary nucleus, supramammillary and submammillothalamic nuclei and the B9 area. Possible excitatory amino acid afferents were identified with retrograde D-[3H]aspartate labelling. Microinjection of D-[3H]aspartate at a low concentration, 10(-4) M in 50 nl, resulted in retrograde labelling of a limited number of median raphe afferents. The most prominent labelling was observed in the lateral habenula and the interpeduncular nucleus, but retrogradely labelled cells were also noted in the medial and lateral preoptic areas, lateral and dorsal hypothalamus, ventral tegmental area, laterodorsal tegmental nucleus, medial parabrachial nucleus, and the pontine tegmentum. After injections of 10(-3) M D-[3H]aspartate selective labelling also appeared in more distant afferent regions, including cells in cingulate cortex, and in some regions located at shorter distances, such as the supramammillary nucleus. Injections of D-[3H]aspartate at high concentration, 10(-2) M, resulted in the appearance of weakly to moderately labelled cells in most afferent areas which were devoid of labelled cells after injections of lower concentrations, suggesting that this labelling may be non-specific. It was concluded that the median-paramedian raphe receives afferents from a large number of forebrain and hypothalamic regions, while relatively few brain stem regions project to this nuclear complex. The selectivity of retrograde labelling with D-[3H]aspartate was found to be concentration dependent, and it is suggested that the connections showing high affinity for D-[3H]aspartate may use excitatory amino acids as transmitters. Excitatory amino acid inputs from lateral habenula and interpeduncular nucleus may play predominant roles in the control of ascending serotonergic and non-serotonergic projections originating in the median and paramedian raphe nuclei." @default.
• W1997716013 created "2016-06-24" @default.
• W1997716013 creator A5039824945 @default.
• W1997716013 creator A5047294572 @default.
• W1997716013 creator A5058028504 @default.
• W1997716013 creator A5070362495 @default.
• W1997716013 date "1990-01-01" @default.
• W1997716013 modified "2023-10-07" @default.
• W1997716013 title "Afferents to the median raphe nucleus of the rat: Retrograde cholera toxin and wheat germ conjugated horseradish peroxidase tracing, and selectived-[3H]aspartate labelling of possible excitatory amino acid inputs" @default.
• W1997716013 cites W1964922357 @default.
• W1997716013 cites W1966079000 @default.
• W1997716013 cites W1966101477 @default.
• W1997716013 cites W1966685026 @default.
• W1997716013 cites W1968345038 @default.
• W1997716013 cites W1968358098 @default.
• W1997716013 cites W1970572555 @default.
• W1997716013 cites W1973487315 @default.
• W1997716013 cites W1974869837 @default.
• W1997716013 cites W1977448784 @default.
• W1997716013 cites W1981119192 @default.
• W1997716013 cites W1984620698 @default.
• W1997716013 cites W1985023977 @default.
• W1997716013 cites W1986262823 @default.
• W1997716013 cites W1987107045 @default.
• W1997716013 cites W1990092109 @default.
• W1997716013 cites W1993320854 @default.
• W1997716013 cites W1993412490 @default.
• W1997716013 cites W1996481778 @default.
• W1997716013 cites W1997653797 @default.
• W1997716013 cites W1998664936 @default.
• W1997716013 cites W1999165328 @default.
• W1997716013 cites W2000734195 @default.
• W1997716013 cites W2003589127 @default.
• W1997716013 cites W2003774045 @default.
• W1997716013 cites W2008574754 @default.
• W1997716013 cites W2012540168 @default.
• W1997716013 cites W2012675076 @default.
• W1997716013 cites W2012729010 @default.
• W1997716013 cites W2013404996 @default.
• W1997716013 cites W2014311492 @default.
• W1997716013 cites W2016648535 @default.
• W1997716013 cites W2017089787 @default.
• W1997716013 cites W2018222414 @default.
• W1997716013 cites W2019244105 @default.
• W1997716013 cites W2020460680 @default.
• W1997716013 cites W2022174379 @default.
• W1997716013 cites W2025377292 @default.
• W1997716013 cites W2028213659 @default.
• W1997716013 cites W2031857349 @default.
• W1997716013 cites W2031951620 @default.
• W1997716013 cites W2034603599 @default.
• W1997716013 cites W2036214063 @default.
• W1997716013 cites W2037523402 @default.
• W1997716013 cites W2038103512 @default.
• W1997716013 cites W2040246407 @default.
• W1997716013 cites W2042252144 @default.
• W1997716013 cites W2044337759 @default.
• W1997716013 cites W2045290451 @default.
• W1997716013 cites W2046227869 @default.
• W1997716013 cites W2047227717 @default.
• W1997716013 cites W2047692008 @default.
• W1997716013 cites W2048898744 @default.
• W1997716013 cites W2050710630 @default.
• W1997716013 cites W2051741454 @default.
• W1997716013 cites W2054281595 @default.
• W1997716013 cites W2054683291 @default.
• W1997716013 cites W2055278273 @default.
• W1997716013 cites W2055931063 @default.
• W1997716013 cites W2059182096 @default.
• W1997716013 cites W2059623974 @default.
• W1997716013 cites W2064469548 @default.
• W1997716013 cites W2064754038 @default.
• W1997716013 cites W2066425999 @default.
• W1997716013 cites W2067071952 @default.
• W1997716013 cites W2067847619 @default.
• W1997716013 cites W2070111250 @default.
• W1997716013 cites W2071154143 @default.
• W1997716013 cites W2071751312 @default.
• W1997716013 cites W2073003311 @default.
• W1997716013 cites W2075236615 @default.
• W1997716013 cites W2075647293 @default.
• W1997716013 cites W2076332121 @default.
• W1997716013 cites W2077403804 @default.
• W1997716013 cites W2078511218 @default.
• W1997716013 cites W2078964253 @default.
• W1997716013 cites W2081188214 @default.
• W1997716013 cites W2081248007 @default.
• W1997716013 cites W2081249119 @default.
• W1997716013 cites W2085445754 @default.
• W1997716013 cites W2085582971 @default.
• W1997716013 cites W2085879471 @default.
• W1997716013 cites W2089166244 @default.
• W1997716013 cites W2089861942 @default.
• W1997716013 cites W2091973393 @default.
• W1997716013 cites W2094339536 @default.
• W1997716013 cites W2094526136 @default.
• W1997716013 cites W2097168340 @default.
• W1997716013 cites W2101774960 @default.

• next