FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997732724> ?p ?o ?g. }

• W1997732724 endingPage "6352" @default.
• W1997732724 startingPage "6347" @default.
• W1997732724 abstract "Small intestine plasmacytoid dendritic cells (pDC) are poorly characterized. Here, we demonstrate that intestinal pDC show the characteristic plasma cell-like morphology, and are recognized by antibodies against B220, Ly6c, 120G8, and PDCA-1, markers that are typically expressed by pDC. Furthermore, intestinal pDC carry high levels of CCR9 and are largely absent in the intestine, but not in lung, liver, or secondary lymphoid organs of CCR9-deficient animals. Competitive adoptive transfers reveal that CCR9-deficient pDC are impaired in homing to the small intestine after i.v. transfer. In a model of cholera toxin-induced gut inflammation, pDC are recruited to the intestine in WT but not CCR9-deficient animals. Furthermore, after oral application of a Toll-like receptor (TLR) 7/8 ligand, myeloid DC of the lamina propria are rapidly mobilized in WT but not in CCR9-deficient animals. Mobilization of myeloid DC can be completely rescued by adoptively transferred WT pDC to CCR9-deficient mice before oral challenge. Together, our data reveal an essential role for CCR9 in the homing of pDC to the intestine under homeostatic and inflammatory conditions and demonstrate an important role for intestinal pDC for the rapid mobilization of lamina propria DC." @default.
• W1997732724 created "2016-06-24" @default.
• W1997732724 creator A5007802405 @default.
• W1997732724 creator A5020235177 @default.
• W1997732724 creator A5041221280 @default.
• W1997732724 creator A5051030997 @default.
• W1997732724 creator A5065576952 @default.
• W1997732724 creator A5082112516 @default.
• W1997732724 creator A5052854787 @default.
• W1997732724 date "2007-04-10" @default.
• W1997732724 modified "2023-10-16" @default.
• W1997732724 title "CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine" @default.
• W1997732724 cites W1493941926 @default.
• W1997732724 cites W1517310071 @default.
• W1997732724 cites W1581270372 @default.
• W1997732724 cites W1925863651 @default.
• W1997732724 cites W1967879964 @default.
• W1997732724 cites W1991390262 @default.
• W1997732724 cites W2006772331 @default.
• W1997732724 cites W2048288058 @default.
• W1997732724 cites W2057725997 @default.
• W1997732724 cites W2090235914 @default.
• W1997732724 cites W2090640877 @default.
• W1997732724 cites W2100051740 @default.
• W1997732724 cites W2102130872 @default.
• W1997732724 cites W2107265716 @default.
• W1997732724 cites W2118647619 @default.
• W1997732724 cites W2129235125 @default.
• W1997732724 cites W2132411790 @default.
• W1997732724 cites W2138780833 @default.
• W1997732724 cites W2151636903 @default.
• W1997732724 cites W2156150500 @default.
• W1997732724 cites W2156831625 @default.
• W1997732724 cites W2161428900 @default.
• W1997732724 cites W2168364423 @default.
• W1997732724 cites W4256399029 @default.
• W1997732724 doi "https://doi.org/10.1073/pnas.0609180104" @default.
• W1997732724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1851094" @default.
• W1997732724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17404233" @default.
• W1997732724 hasPublicationYear "2007" @default.
• W1997732724 type Work @default.
• W1997732724 sameAs 1997732724 @default.
• W1997732724 citedByCount "210" @default.
• W1997732724 countsByYear W19977327242012 @default.
• W1997732724 countsByYear W19977327242013 @default.
• W1997732724 countsByYear W19977327242014 @default.
• W1997732724 countsByYear W19977327242015 @default.
• W1997732724 countsByYear W19977327242016 @default.
• W1997732724 countsByYear W19977327242017 @default.
• W1997732724 countsByYear W19977327242018 @default.
• W1997732724 countsByYear W19977327242019 @default.
• W1997732724 countsByYear W19977327242020 @default.
• W1997732724 countsByYear W19977327242021 @default.
• W1997732724 countsByYear W19977327242022 @default.
• W1997732724 countsByYear W19977327242023 @default.
• W1997732724 crossrefType "journal-article" @default.
• W1997732724 hasAuthorship W1997732724A5007802405 @default.
• W1997732724 hasAuthorship W1997732724A5020235177 @default.
• W1997732724 hasAuthorship W1997732724A5041221280 @default.
• W1997732724 hasAuthorship W1997732724A5051030997 @default.
• W1997732724 hasAuthorship W1997732724A5052854787 @default.
• W1997732724 hasAuthorship W1997732724A5065576952 @default.
• W1997732724 hasAuthorship W1997732724A5082112516 @default.
• W1997732724 hasBestOaLocation W19977327244 @default.
• W1997732724 hasConcept C126322002 @default.
• W1997732724 hasConcept C134018914 @default.
• W1997732724 hasConcept C147483822 @default.
• W1997732724 hasConcept C151872237 @default.
• W1997732724 hasConcept C170493617 @default.
• W1997732724 hasConcept C18903297 @default.
• W1997732724 hasConcept C203014093 @default.
• W1997732724 hasConcept C2776090121 @default.
• W1997732724 hasConcept C2777310793 @default.
• W1997732724 hasConcept C2777882243 @default.
• W1997732724 hasConcept C2779282312 @default.
• W1997732724 hasConcept C3019368612 @default.
• W1997732724 hasConcept C43667030 @default.
• W1997732724 hasConcept C529295009 @default.
• W1997732724 hasConcept C54355233 @default.
• W1997732724 hasConcept C71924100 @default.
• W1997732724 hasConcept C86803240 @default.
• W1997732724 hasConcept C8891405 @default.
• W1997732724 hasConcept C90375314 @default.
• W1997732724 hasConcept C95444343 @default.
• W1997732724 hasConceptScore W1997732724C126322002 @default.
• W1997732724 hasConceptScore W1997732724C134018914 @default.
• W1997732724 hasConceptScore W1997732724C147483822 @default.
• W1997732724 hasConceptScore W1997732724C151872237 @default.
• W1997732724 hasConceptScore W1997732724C170493617 @default.
• W1997732724 hasConceptScore W1997732724C18903297 @default.
• W1997732724 hasConceptScore W1997732724C203014093 @default.
• W1997732724 hasConceptScore W1997732724C2776090121 @default.
• W1997732724 hasConceptScore W1997732724C2777310793 @default.
• W1997732724 hasConceptScore W1997732724C2777882243 @default.
• W1997732724 hasConceptScore W1997732724C2779282312 @default.
• W1997732724 hasConceptScore W1997732724C3019368612 @default.
• W1997732724 hasConceptScore W1997732724C43667030 @default.
• W1997732724 hasConceptScore W1997732724C529295009 @default.

• next