Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997733088> ?p ?o ?g. }
- W1997733088 endingPage "706" @default.
- W1997733088 startingPage "696" @default.
- W1997733088 abstract "Post-traumatic depression (PTD) may be a result of several factors like secondary injury chemical cascades as well as psycho-social factors following traumatic brain injury (TBI). While the role of serotonin in the pathology and treatment of idiopathic major depression may be somewhat controversial, it is unclear what role serotonin may play in PTD following a TBI.To assess serotonergic function and genetic risk for PTD development over 1 year following TBI.Examination of variation in the serotonin transporter gene [SLC6A4 (5-HTTLPR, rs25331, and a variable number of tandem repeats variant in Intron 2)] in 109 subjects with moderate-severe injury. Depression was assessed using the Patient Health Questionnaire (PHQ-9) at 6 and/or 12 months post-injury.At 6 months post-injury, subjects with a history of pre-morbid mood disorders and 5-HTTLPR L-homozygotes were at greater risk for PTD. Contrary to major depression, subjects without pre-morbid mood disorders (n = 80) and S-carriers were 2.803-times less likely to be depressed compared to L-homozygotes. At 12 months post-injury, LG-carriers were also less likely to experience PTD. Temporal analysis also showed 5-HTTLPR associations in PTD development across recovery.This study suggests a unique injury- and temporally-specific interaction between TBI and genetic risk for depression." @default.
- W1997733088 created "2016-06-24" @default.
- W1997733088 creator A5013561770 @default.
- W1997733088 creator A5016803157 @default.
- W1997733088 creator A5016824373 @default.
- W1997733088 creator A5039442562 @default.
- W1997733088 creator A5068144784 @default.
- W1997733088 creator A5071539931 @default.
- W1997733088 creator A5043245839 @default.
- W1997733088 date "2013-04-05" @default.
- W1997733088 modified "2023-09-26" @default.
- W1997733088 title "Variants of SLC6A4 in depression risk following severe TBI" @default.
- W1997733088 cites W1603121691 @default.
- W1997733088 cites W1965155730 @default.
- W1997733088 cites W1966161647 @default.
- W1997733088 cites W197086841 @default.
- W1997733088 cites W1977263445 @default.
- W1997733088 cites W1981665280 @default.
- W1997733088 cites W1981918518 @default.
- W1997733088 cites W1982255698 @default.
- W1997733088 cites W1984455353 @default.
- W1997733088 cites W1986286347 @default.
- W1997733088 cites W1990367960 @default.
- W1997733088 cites W1992661571 @default.
- W1997733088 cites W1995234726 @default.
- W1997733088 cites W2005534453 @default.
- W1997733088 cites W2010604180 @default.
- W1997733088 cites W2011793525 @default.
- W1997733088 cites W2015038120 @default.
- W1997733088 cites W2019096454 @default.
- W1997733088 cites W2024142896 @default.
- W1997733088 cites W2024799025 @default.
- W1997733088 cites W2042156043 @default.
- W1997733088 cites W2042170262 @default.
- W1997733088 cites W2044784291 @default.
- W1997733088 cites W2045722213 @default.
- W1997733088 cites W2045839402 @default.
- W1997733088 cites W2046496887 @default.
- W1997733088 cites W2055354052 @default.
- W1997733088 cites W2060242158 @default.
- W1997733088 cites W2060345033 @default.
- W1997733088 cites W2067940063 @default.
- W1997733088 cites W2071804866 @default.
- W1997733088 cites W2073687865 @default.
- W1997733088 cites W2080846594 @default.
- W1997733088 cites W2086530310 @default.
- W1997733088 cites W2087170847 @default.
- W1997733088 cites W2093179738 @default.
- W1997733088 cites W2096181156 @default.
- W1997733088 cites W2106095564 @default.
- W1997733088 cites W2106623141 @default.
- W1997733088 cites W2109026965 @default.
- W1997733088 cites W2125901028 @default.
- W1997733088 cites W2135916631 @default.
- W1997733088 cites W2136942291 @default.
- W1997733088 cites W2141185284 @default.
- W1997733088 cites W2147351252 @default.
- W1997733088 cites W2147909291 @default.
- W1997733088 cites W2150523152 @default.
- W1997733088 cites W2156178535 @default.
- W1997733088 cites W2156791952 @default.
- W1997733088 cites W2157106133 @default.
- W1997733088 cites W2158628761 @default.
- W1997733088 cites W2170684975 @default.
- W1997733088 cites W2171097731 @default.
- W1997733088 cites W2335446974 @default.
- W1997733088 cites W2736091234 @default.
- W1997733088 cites W4301894936 @default.
- W1997733088 doi "https://doi.org/10.3109/02699052.2013.775481" @default.
- W1997733088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23672445" @default.
- W1997733088 hasPublicationYear "2013" @default.
- W1997733088 type Work @default.
- W1997733088 sameAs 1997733088 @default.
- W1997733088 citedByCount "36" @default.
- W1997733088 countsByYear W19977330882014 @default.
- W1997733088 countsByYear W19977330882015 @default.
- W1997733088 countsByYear W19977330882016 @default.
- W1997733088 countsByYear W19977330882017 @default.
- W1997733088 countsByYear W19977330882018 @default.
- W1997733088 countsByYear W19977330882019 @default.
- W1997733088 countsByYear W19977330882021 @default.
- W1997733088 countsByYear W19977330882022 @default.
- W1997733088 crossrefType "journal-article" @default.
- W1997733088 hasAuthorship W1997733088A5013561770 @default.
- W1997733088 hasAuthorship W1997733088A5016803157 @default.
- W1997733088 hasAuthorship W1997733088A5016824373 @default.
- W1997733088 hasAuthorship W1997733088A5039442562 @default.
- W1997733088 hasAuthorship W1997733088A5043245839 @default.
- W1997733088 hasAuthorship W1997733088A5068144784 @default.
- W1997733088 hasAuthorship W1997733088A5071539931 @default.
- W1997733088 hasConcept C118552586 @default.
- W1997733088 hasConcept C126322002 @default.
- W1997733088 hasConcept C139719470 @default.
- W1997733088 hasConcept C15744967 @default.
- W1997733088 hasConcept C162324750 @default.
- W1997733088 hasConcept C170493617 @default.
- W1997733088 hasConcept C2775864247 @default.
- W1997733088 hasConcept C2776867660 @default.