FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997733646> ?p ?o ?g. }

• W1997733646 endingPage "194" @default.
• W1997733646 startingPage "186" @default.
• W1997733646 abstract "Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since the IVA genome does not have the processing protease for the viral hemagglutinin (HA) envelope glycoprotein precursors, entry of this virus into cells and infectious organ tropism of IAV are primarily determined by host cellular trypsin-type HA processing proteases. Several secretion-type HA processing proteases for seasonal IAV in the airway, and ubiquitously expressed furin and pro-protein convertases for highly pathogenic avian influenza (HPAI) virus, have been reported. Recently, other HA-processing proteases for seasonal IAV and HPAI have been identified in the membrane fraction. These proteases proteolytically activate viral multiplication at the time of viral entry and budding. In addition to the role of host cellular proteases in IAV pathogenicity, IAV infection results in marked upregulation of cellular trypsins and matrix metalloproteinase-9 in various organs and cells, particularly endothelial cells, through induced pro-inflammatory cytokines. These host cellular factors interact with each other as the influenza virus-cytokine-protease cycle, which is the major mechanism that induces vascular hyperpermeability and multiorgan failure in severe influenza. This mini-review discusses the roles of cellular proteases in the pathogenesis of IAV and highlights the molecular mechanisms of upregulation of trypsins as effective targets for the control of IAV infection. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome." @default.
• W1997733646 created "2016-06-24" @default.
• W1997733646 creator A5007873838 @default.
• W1997733646 creator A5022571998 @default.
• W1997733646 creator A5028201702 @default.
• W1997733646 creator A5036669859 @default.
• W1997733646 creator A5050849944 @default.
• W1997733646 creator A5068390829 @default.
• W1997733646 creator A5087962680 @default.
• W1997733646 creator A5088480448 @default.
• W1997733646 creator A5090661259 @default.
• W1997733646 date "2012-01-01" @default.
• W1997733646 modified "2023-10-04" @default.
• W1997733646 title "Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure" @default.
• W1997733646 cites W114652413 @default.
• W1997733646 cites W1480056716 @default.
• W1997733646 cites W1507765665 @default.
• W1997733646 cites W1507840484 @default.
• W1997733646 cites W1510483945 @default.
• W1997733646 cites W1558753212 @default.
• W1997733646 cites W1563019217 @default.
• W1997733646 cites W1587597864 @default.
• W1997733646 cites W1672939180 @default.
• W1997733646 cites W1899890796 @default.
• W1997733646 cites W1964245344 @default.
• W1997733646 cites W1965152120 @default.
• W1997733646 cites W1974043792 @default.
• W1997733646 cites W1974355337 @default.
• W1997733646 cites W1982365129 @default.
• W1997733646 cites W1982506325 @default.
• W1997733646 cites W1984247755 @default.
• W1997733646 cites W1985131865 @default.
• W1997733646 cites W1995362868 @default.
• W1997733646 cites W1997309276 @default.
• W1997733646 cites W2013453931 @default.
• W1997733646 cites W2022527113 @default.
• W1997733646 cites W2039782308 @default.
• W1997733646 cites W2045837603 @default.
• W1997733646 cites W2049305023 @default.
• W1997733646 cites W2050640978 @default.
• W1997733646 cites W2052319450 @default.
• W1997733646 cites W2054435322 @default.
• W1997733646 cites W2069651570 @default.
• W1997733646 cites W2082920591 @default.
• W1997733646 cites W2091089657 @default.
• W1997733646 cites W2092652964 @default.
• W1997733646 cites W2097080554 @default.
• W1997733646 cites W2097128982 @default.
• W1997733646 cites W2099045066 @default.
• W1997733646 cites W2099549544 @default.
• W1997733646 cites W2100862582 @default.
• W1997733646 cites W2102780353 @default.
• W1997733646 cites W2112449607 @default.
• W1997733646 cites W2122017644 @default.
• W1997733646 cites W2122196184 @default.
• W1997733646 cites W2122324926 @default.
• W1997733646 cites W2122399224 @default.
• W1997733646 cites W2147682506 @default.
• W1997733646 cites W2149051606 @default.
• W1997733646 cites W2156638064 @default.
• W1997733646 cites W2160527857 @default.
• W1997733646 cites W2162225087 @default.
• W1997733646 cites W2169066485 @default.
• W1997733646 cites W2170069496 @default.
• W1997733646 cites W2241247373 @default.
• W1997733646 cites W4205775889 @default.
• W1997733646 cites W4242400907 @default.
• W1997733646 cites W4255559572 @default.
• W1997733646 cites W4297744082 @default.
• W1997733646 doi "https://doi.org/10.1016/j.bbapap.2011.07.001" @default.
• W1997733646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21801859" @default.
• W1997733646 hasPublicationYear "2012" @default.
• W1997733646 type Work @default.
• W1997733646 sameAs 1997733646 @default.
• W1997733646 citedByCount "105" @default.
• W1997733646 countsByYear W19977336462012 @default.
• W1997733646 countsByYear W19977336462013 @default.
• W1997733646 countsByYear W19977336462014 @default.
• W1997733646 countsByYear W19977336462015 @default.
• W1997733646 countsByYear W19977336462016 @default.
• W1997733646 countsByYear W19977336462017 @default.
• W1997733646 countsByYear W19977336462018 @default.
• W1997733646 countsByYear W19977336462019 @default.
• W1997733646 countsByYear W19977336462020 @default.
• W1997733646 countsByYear W19977336462021 @default.
• W1997733646 countsByYear W19977336462022 @default.
• W1997733646 countsByYear W19977336462023 @default.
• W1997733646 crossrefType "journal-article" @default.
• W1997733646 hasAuthorship W1997733646A5007873838 @default.
• W1997733646 hasAuthorship W1997733646A5022571998 @default.
• W1997733646 hasAuthorship W1997733646A5028201702 @default.
• W1997733646 hasAuthorship W1997733646A5036669859 @default.
• W1997733646 hasAuthorship W1997733646A5050849944 @default.
• W1997733646 hasAuthorship W1997733646A5068390829 @default.
• W1997733646 hasAuthorship W1997733646A5087962680 @default.
• W1997733646 hasAuthorship W1997733646A5088480448 @default.
• W1997733646 hasAuthorship W1997733646A5090661259 @default.
• W1997733646 hasBestOaLocation W19977336461 @default.

• next