FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997736698> ?p ?o ?g. }

• W1997736698 endingPage "1802" @default.
• W1997736698 startingPage "1785" @default.
• W1997736698 abstract "The Na+ + K+ + Mg2+ —dependent adenosine triphosphate phosphohydrolase system (transport ATPase) from the heart muscle of dog, cat, man (fetus), pigeon, guinea-pig, frog, rat and toad was studied. The transport ATPases of the eight species are equally strongly inhibited by calcium ions, they show, however, great variations of the susceptibility to inhibition by the cardiotonic drugs ouabain, digitoxin, cassaine and prednisolone-3,20-bis-guanylhydrazone. The species variations in the inhibitory activity of these cardiotonics are not due to accidental variables or to preparative artefacts, but represent characteristics of the transport ATPases of the various animal species. The cardiotonics compared one with another, differ in the relative strength of the inhibitory effect on the enzymatic systems of various species. The complementarity between the surface of the steroid or terpenoid component of the cardiotonics on the one hand and the surface in the neighbourhood of the K+—centre of the transport ATPase on the other hand is presumed to be the decisive factor for the inhibitory activity of the compounds, because it appears to determine essentially the affinity between the cardiotonic and the enzyme system. Thus, the species variations in the susceptibility of the transport ATPase to inhibition might be caused by species differences in the topography of the neighbourhood of the K+—centre at the outer surface of the cell membrane. The observations on the enzyme level are examined whether they offer an explanation for the species differences of the susceptibility to the therapeutic or toxic actions of ouabain, digitoxin, cassaine or prednisolone-bis-guanylhydrazone. The species dependency of their effects on the enzyme system, the contractility and the intact animal is compared. The results favour the conclusion that the species variations in the susceptibility of the heart muscle and the intact animal to cardiotonics are largely based on corresponding variations in the susceptibility of the different transport ATPases to inhibition by these compounds." @default.
• W1997736698 created "2016-06-24" @default.
• W1997736698 creator A5003024714 @default.
• W1997736698 creator A5007859758 @default.
• W1997736698 creator A5020983655 @default.
• W1997736698 date "1965-12-01" @default.
• W1997736698 modified "2023-09-26" @default.
• W1997736698 title "Über die ursache der speciesunterschiede in der digitalisempfindlichkeit" @default.
• W1997736698 cites W1506043065 @default.
• W1997736698 cites W1967585479 @default.
• W1997736698 cites W1973468502 @default.
• W1997736698 cites W1975328649 @default.
• W1997736698 cites W1984381407 @default.
• W1997736698 cites W1985546290 @default.
• W1997736698 cites W1992941690 @default.
• W1997736698 cites W1992979672 @default.
• W1997736698 cites W1993918054 @default.
• W1997736698 cites W1994494842 @default.
• W1997736698 cites W2004990092 @default.
• W1997736698 cites W2021812744 @default.
• W1997736698 cites W2042654564 @default.
• W1997736698 cites W2049816277 @default.
• W1997736698 cites W2058879102 @default.
• W1997736698 cites W2060131908 @default.
• W1997736698 cites W2060468520 @default.
• W1997736698 cites W2063460855 @default.
• W1997736698 cites W2071588192 @default.
• W1997736698 cites W2083803773 @default.
• W1997736698 cites W2089212703 @default.
• W1997736698 cites W2305835758 @default.
• W1997736698 cites W2345116176 @default.
• W1997736698 cites W2409483161 @default.
• W1997736698 cites W2415498668 @default.
• W1997736698 cites W4237870962 @default.
• W1997736698 doi "https://doi.org/10.1016/0006-2952(65)90269-8" @default.
• W1997736698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4222534" @default.
• W1997736698 hasPublicationYear "1965" @default.
• W1997736698 type Work @default.
• W1997736698 sameAs 1997736698 @default.
• W1997736698 citedByCount "183" @default.
• W1997736698 countsByYear W19977366982021 @default.
• W1997736698 countsByYear W19977366982022 @default.
• W1997736698 crossrefType "journal-article" @default.
• W1997736698 hasAuthorship W1997736698A5003024714 @default.
• W1997736698 hasAuthorship W1997736698A5007859758 @default.
• W1997736698 hasAuthorship W1997736698A5020983655 @default.
• W1997736698 hasConcept C126322002 @default.
• W1997736698 hasConcept C129513315 @default.
• W1997736698 hasConcept C134018914 @default.
• W1997736698 hasConcept C17077164 @default.
• W1997736698 hasConcept C178790620 @default.
• W1997736698 hasConcept C181199279 @default.
• W1997736698 hasConcept C185592680 @default.
• W1997736698 hasConcept C18903297 @default.
• W1997736698 hasConcept C23265538 @default.
• W1997736698 hasConcept C2777707475 @default.
• W1997736698 hasConcept C2778198053 @default.
• W1997736698 hasConcept C2778815084 @default.
• W1997736698 hasConcept C2779133857 @default.
• W1997736698 hasConcept C2780628665 @default.
• W1997736698 hasConcept C537181965 @default.
• W1997736698 hasConcept C55493867 @default.
• W1997736698 hasConcept C71924100 @default.
• W1997736698 hasConcept C76854278 @default.
• W1997736698 hasConcept C86803240 @default.
• W1997736698 hasConceptScore W1997736698C126322002 @default.
• W1997736698 hasConceptScore W1997736698C129513315 @default.
• W1997736698 hasConceptScore W1997736698C134018914 @default.
• W1997736698 hasConceptScore W1997736698C17077164 @default.
• W1997736698 hasConceptScore W1997736698C178790620 @default.
• W1997736698 hasConceptScore W1997736698C181199279 @default.
• W1997736698 hasConceptScore W1997736698C185592680 @default.
• W1997736698 hasConceptScore W1997736698C18903297 @default.
• W1997736698 hasConceptScore W1997736698C23265538 @default.
• W1997736698 hasConceptScore W1997736698C2777707475 @default.
• W1997736698 hasConceptScore W1997736698C2778198053 @default.
• W1997736698 hasConceptScore W1997736698C2778815084 @default.
• W1997736698 hasConceptScore W1997736698C2779133857 @default.
• W1997736698 hasConceptScore W1997736698C2780628665 @default.
• W1997736698 hasConceptScore W1997736698C537181965 @default.
• W1997736698 hasConceptScore W1997736698C55493867 @default.
• W1997736698 hasConceptScore W1997736698C71924100 @default.
• W1997736698 hasConceptScore W1997736698C76854278 @default.
• W1997736698 hasConceptScore W1997736698C86803240 @default.
• W1997736698 hasIssue "12" @default.
• W1997736698 hasLocation W19977366981 @default.
• W1997736698 hasLocation W19977366982 @default.
• W1997736698 hasOpenAccess W1997736698 @default.
• W1997736698 hasPrimaryLocation W19977366981 @default.
• W1997736698 hasRelatedWork W1993295939 @default.
• W1997736698 hasRelatedWork W1997736698 @default.
• W1997736698 hasRelatedWork W2015689418 @default.
• W1997736698 hasRelatedWork W2018172989 @default.
• W1997736698 hasRelatedWork W2030887773 @default.
• W1997736698 hasRelatedWork W2031587531 @default.
• W1997736698 hasRelatedWork W2047670402 @default.
• W1997736698 hasRelatedWork W2057579353 @default.
• W1997736698 hasRelatedWork W2058398295 @default.

• next